anovelsarsolenanediterpeneasaptp1binhibitorfromhainansoftcoralsarcophytontrocheliophorummarenzeller
文献类型：期刊论文
| 作者 | Liang Linfu2; Wang Jinan1; Shi Xiaoxuan2; Zhu Yinghua2; Li Jia1 ; Zhu Weiliang1; Wang Heyao1; Guo Yuewei1
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| 刊名 | chinesejournalofchemistry
 |
| 出版日期 | 2017 |
| 卷号 | 35期号:8页码:1246 |
| 关键词 | Sarcophyton trocheliophrum sarsolenane structure elucidation PTP1B inhibitory activity binding mode |
| ISSN号 | 1001-604X |
| DOI | 10.1002/cjoc.201600819 |
| 英文摘要 | A novel sarsolenane diterpene, named secodihydrosarsolenone (1), as a minor component was obtained from the South China Sea soft coral Sarcophyton trocheliophorum Marenzeller. Its structure was elucidated by detailed spectroscopic analysis. Compound 1 exhibited moderate inhibitory activity (IC_(50)=13.7 μmol·L~(-1)) against protein tyrosine phosphatase 1B (PTP1B),a key target for the treatment of type 2 diabetes, representing the first report of PTP1B inhibitory activity for sarsolenane diterpenes. This discovery promotes computational prediction of binding mode between the enzyme and the metabolite, suggesting a crucial role of the residues Tyr46, Ser216 and Arg221 in the binding action. |
| 语种 | 英语 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/282911]  |
| 专题 | 中国科学院上海药物研究所 |
| 作者单位 | 1.中国科学院上海药物研究所 2.中南林业科技大学 |
| 推荐引用方式 GB/T 7714 | Liang Linfu,Wang Jinan,Shi Xiaoxuan,et al. anovelsarsolenanediterpeneasaptp1binhibitorfromhainansoftcoralsarcophytontrocheliophorummarenzeller[J]. chinesejournalofchemistry,2017,35(8):1246. |
| APA | Liang Linfu.,Wang Jinan.,Shi Xiaoxuan.,Zhu Yinghua.,Li Jia.,...&Guo Yuewei.(2017).anovelsarsolenanediterpeneasaptp1binhibitorfromhainansoftcoralsarcophytontrocheliophorummarenzeller.chinesejournalofchemistry,35(8),1246. |
| MLA | Liang Linfu,et al."anovelsarsolenanediterpeneasaptp1binhibitorfromhainansoftcoralsarcophytontrocheliophorummarenzeller".chinesejournalofchemistry 35.8(2017):1246. |
入库方式： OAI收割
来源：上海药物研究所
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