policresulenanovelns2bns3proteaseinhibitoreffectivelyinhibitsthereplicationofdenv2virusinbhk21cells
文献类型：期刊论文
| 作者 | Wu Dengwei1; Mao Fei2; Ye Yan3; Li Jian2; Xu Chuanlian1; Luo Xiaomin3 ; Chen Jing3; Shen Xu3
|
| 刊名 | actapharmacologicasinica
 |
| 出版日期 | 2015 |
| 卷号 | 36期号:9页码:1126 |
| 关键词 | SMALL-MOLECULE INHIBITORS STRUCTURE-BASED DISCOVERY DRUG-LIKE MOLECULES DENGUE VIRUS SERINE-PROTEASE NS3 PROTEASE PEPTIDE INHIBITORS NS2B-NS3 PROTEASE ACCURATE DOCKING IN-VITRO Dengue virus antiviral drug NS2B/NS3 protease policresulen molecular docking molecular modeling |
| ISSN号 | 1671-4083 |
| DOI | 10.1038/aps.2015.56 |
| 英文摘要 | Aim: Dengue is a severe epidemic disease caused by dengue virus (DENV) infection, for which no effective treatment is available. The protease complex, consisting of nonstructural protein 3 (NS3) and its cofactor NS2B, plays a pivotal role in the replication of DENV, thus may be a potential target for anti-DENV drugs. Here, we report a novel inhibitor of DENV2 NS2B/NS3 protease and its antiviral action. |
| 资助项目 | [National Natural Science Foundation of China] |
| 语种 | 英语 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/282969]  |
| 专题 | 中国科学院上海药物研究所 |
| 作者单位 | 1.浙江理工大学 2.华东理工大学 3.中国科学院上海药物研究所 |
| 推荐引用方式 GB/T 7714 | Wu Dengwei,Mao Fei,Ye Yan,et al. policresulenanovelns2bns3proteaseinhibitoreffectivelyinhibitsthereplicationofdenv2virusinbhk21cells[J]. actapharmacologicasinica,2015,36(9):1126. |
| APA | Wu Dengwei.,Mao Fei.,Ye Yan.,Li Jian.,Xu Chuanlian.,...&Shen Xu.(2015).policresulenanovelns2bns3proteaseinhibitoreffectivelyinhibitsthereplicationofdenv2virusinbhk21cells.actapharmacologicasinica,36(9),1126. |
| MLA | Wu Dengwei,et al."policresulenanovelns2bns3proteaseinhibitoreffectivelyinhibitsthereplicationofdenv2virusinbhk21cells".actapharmacologicasinica 36.9(2015):1126. |
入库方式： OAI收割
来源：上海药物研究所
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