magnesiumlithospermatebamelioratesrenalcorticalmicroperfusioninrats
文献类型：期刊论文
| 作者 | Chunguang Chen1; Yiping Wang2
|
| 刊名 | actapharmacologicasinica
 |
| 出版日期 | 2006 |
| 卷号 | 27期号:2页码:217 |
| 关键词 | NITRIC-OXIDE VASCULAR-RESISTANCE SALVIA-MILTIORRHIZA OXYGEN RADICALS FAILURE PROSTAGLANDINS SUPEROXIDE RESPONSES KIDNEY INJURY magnesium lithospermate B hemodynamics renal blood flow renal cortical microperfusion |
| ISSN号 | 1671-4083 |
| DOI | 10.1111/j.1745-7254.2006.00225.x |
| 英文摘要 | Aim: To investigate the effects of magnesium lithospermate B (MLB) isolated from Salviae miltiorrhizae on renal microcirculation, and renal and systemic hemodynamics in Sprague-Dawley rats. Methods: MLB (10, 30, and 60 mg/kg) was injected intravenously and renal blood flow (RBF), renal cortical microperfusion (RCM), and systemic hemodynamic function parameters including heart rate (HR), mean arterial pressure (MAP), left ventricular systolic pressure (LVSP), left ventricular end-diastolic pressure (LVEDP), and maximal velocity of pressure increase (dp/dt(max)) were measured for 45 min after administration. Results: Intravenous MLB at doses of 10, 30, and 60 mg/kg increased RCM significantly, but had no obvious effects on RBF or systemic hemodynamics. The effect of MLB on RCM reached its peak 15 min after injection and returned to baseline after 45 min. Up to 60 mg/kg MLB increased RCM by 62.4%+/- 20.2% (changes from baseline, P < 0.01), whereas RBF (3.7%+/- 9.7% vs baseline) and renal vascular resistance (-1.4%+/- 9.1% vs baseline) did not obviously change. Conclusion: These results indicate that MLB ameliorates renal microcirculation in a dose-dependent manner, which may be related to the renoprotective effects of MLB. |
| 语种 | 英语 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/282979]  |
| 专题 | 中国科学院上海药物研究所 |
| 作者单位 | 1.中国科学院上海生命科学研究院 2.中国科学院上海药物研究所 |
| 推荐引用方式 GB/T 7714 | Chunguang Chen,Yiping Wang. magnesiumlithospermatebamelioratesrenalcorticalmicroperfusioninrats[J]. actapharmacologicasinica,2006,27(2):217. |
| APA | Chunguang Chen,&Yiping Wang.(2006).magnesiumlithospermatebamelioratesrenalcorticalmicroperfusioninrats.actapharmacologicasinica,27(2),217. |
| MLA | Chunguang Chen,et al."magnesiumlithospermatebamelioratesrenalcorticalmicroperfusioninrats".actapharmacologicasinica 27.2(2006):217. |
入库方式： OAI收割
来源：上海药物研究所
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