designandsynthesisofnoveltriazolederivativescontainingglactamaspotentialantifungalagents
文献类型：期刊论文
| 作者 | Xu Yuanyuan1; Qian Anran1; Cao Xufeng1; Ling Chenyu1; Cao Yongbing2; Wang Ruilian2; Li Yisu1; Yang Yushe1
|
| 刊名 | chinesechemicalletters
 |
| 出版日期 | 2016 |
| 卷号 | 27期号:5页码:703 |
| 关键词 | Synthesis Triazole g-Lactam Antifungal activity |
| ISSN号 | 1001-8417 |
| DOI | 10.1016/j.cclet.2016.01.040 |
| 英文摘要 | A series of novel triazole derivatives containing g-lactam were designed and synthesized, and their structures were confirmed by ~1H NMR, ~(13)C NMR and HRMS. The in vitro antifungal activities of the target compounds were evaluated. The results showed that all of the compounds exhibited stronger activity against the six clinically important fungi tested than fluconazole. 3D and 3E showed comparative activity against the fungi tested except for Candida glabrata and Aspergillus fumigatus as voriconazole. In addition, the docking model for 2A and CYP51 was investigated. |
| 语种 | 英语 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/283076]  |
| 专题 | 中国科学院上海药物研究所 |
| 作者单位 | 1.中国科学院上海药物研究所 2.中国人民解放军第二军医大学 |
| 推荐引用方式 GB/T 7714 | Xu Yuanyuan,Qian Anran,Cao Xufeng,et al. designandsynthesisofnoveltriazolederivativescontainingglactamaspotentialantifungalagents[J]. chinesechemicalletters,2016,27(5):703. |
| APA | Xu Yuanyuan.,Qian Anran.,Cao Xufeng.,Ling Chenyu.,Cao Yongbing.,...&Yang Yushe.(2016).designandsynthesisofnoveltriazolederivativescontainingglactamaspotentialantifungalagents.chinesechemicalletters,27(5),703. |
| MLA | Xu Yuanyuan,et al."designandsynthesisofnoveltriazolederivativescontainingglactamaspotentialantifungalagents".chinesechemicalletters 27.5(2016):703. |
入库方式： OAI收割
来源：上海药物研究所
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