23benzoylthioureido4567tetrahydrobenzobthiophene3carboxylicacidamelioratesmetabolicdisordersinhighfatdietfedmice
文献类型：期刊论文
| 作者 | Zhang Jin1; Zhang Lina2; Chen Dongmei1; Fu Yanyun2; Zhang Feng1; Yang Lingling1; Xia Chunmei2; Jiang Haowen1; Tang ChunIan2; Xie Zhifu2 |
| 刊名 | actapharmacologicasinica
 |
| 出版日期 | 2015 |
| 卷号 | 36期号:4页码:483 |
| ISSN号 | 1671-4083 |
| 关键词 | ACTIVATED PROTEIN-KINASE ELEMENT-BINDING PROTEIN-1C INSULIN-RESISTANCE LIVER-DISEASE TRANSCRIPTION FACTOR DIABETES-MELLITUS HEPATIC STEATOSIS CULTURED-CELLS SREBP ACTIVITY DIRECT TARGET 2-(3-benzoylthioureido)-4,5,6,7-tetrahydrobenzob thiophene-3-carboxylic acid lipogenesis SREBP-1c AMPK mTOR hepatic lipid accumulation obesity metabolic disorders |
| DOI | 10.1038/aps.2014.149 |
| 英文摘要 | Aim: Sterol-regulatory element binding proteins (SREBPs) are major transcription factors that regulate liver lipid biosynthesis. In this article we reported a novel synthetic compound 2-(3-benzoylthioureido)-4,5,6,7-tetrahydrobenzob thiophene-3-carboxylic acid (ZJ001) that inhibited the SREBP-1c pathway, and effectively reduced hepatic lipid accumulation in diet-induced obesity (DIO) mice. |
| 资助项目 | [National Program on Key Basic Research Project (973 Program)] ; [National Science and Technology Major Projects for "Major New Drugs Innovation and Development"] ; [National Natural Science Foundation of China] |
| 语种 | 英语 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/283093]  |
| 专题 | 中国科学院上海药物研究所 |
| 作者单位 | 1.华东师范大学 2.中国科学院上海药物研究所 |
| 推荐引用方式 GB/T 7714 | Zhang Jin,Zhang Lina,Chen Dongmei,et al. 23benzoylthioureido4567tetrahydrobenzobthiophene3carboxylicacidamelioratesmetabolicdisordersinhighfatdietfedmice[J]. actapharmacologicasinica,2015,36(4):483. |
| APA | Zhang Jin.,Zhang Lina.,Chen Dongmei.,Fu Yanyun.,Zhang Feng.,...&Li Jingya.(2015).23benzoylthioureido4567tetrahydrobenzobthiophene3carboxylicacidamelioratesmetabolicdisordersinhighfatdietfedmice.actapharmacologicasinica,36(4),483. |
| MLA | Zhang Jin,et al."23benzoylthioureido4567tetrahydrobenzobthiophene3carboxylicacidamelioratesmetabolicdisordersinhighfatdietfedmice".actapharmacologicasinica 36.4(2015):483. |
入库方式： OAI收割
来源：上海药物研究所
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