synthesisandbioassayof14dmannansaspotentialagentsagainstalzheimersdisease
文献类型：期刊论文
| 作者 | Jiang Ruwei; Du Xiaoguang; Zhang Xuan; Wang Xin ; Hu Dingyu; Meng Tao; Chen Yuelei; Geng Meiyu; Shen Jingkang
|
| 刊名 | actapharmacologicasinica
 |
| 出版日期 | 2013 |
| 卷号 | 34期号:12页码:1585 |
| 关键词 | Alzheimer's disease Aβ peptide oligosaccharide β-(1 4)-D-mannan oligomannurarate 971 alzhemed neuroprotection medicinal chemistry |
| ISSN号 | 1671-4083 |
| 英文摘要 | Aim: Oligomannurarate 971 derived from a marine plant has shown neuroprotective effects. In this study we synthesized a series of truncated derivatives of the oligosaccharide, and investigated the effect of these derivatives against Aβ peptide toxicity in vitro. Methods: The sulfoxide method was applied to synthesize the derivatives. SH-SY5Y human neuroblastoma cells were treated with Aβ_(1-40) (2 μmol/L), and the cell viability was detected using a CCK8 assay. Results: A series of β-(1,4)-D-mannosyl oligosaccharide, ranging from the disaccharide to the hexasaccharide, were synthesized. Addition of 10 μmol/L β-(1,4)-D-mannobiose 6, β-(1,4)-D-mannotriose 9 or β-(1,4)-D-mannotetraose 12 in SH-SY5Y cells significantly attenuated Aβ1-40-induced toxicity. The efficacies were similar to those caused by 10 μmol/L oligomannurarate 971 or alzhemed. Other oligosaccharides including oligomaltoses and oligocelluloses were less active. Conclusion: Synthetic homogeneous short chain β-(1,4)-D-mannans shows neuroprotective effect against Aβ peptide toxicity similar to that of heterogeneous oligomannurarate 971 and alzhemed. |
| 语种 | 英语 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/283113]  |
| 专题 | 中国科学院上海药物研究所 |
| 作者单位 | 中国科学院上海药物研究所 |
| 推荐引用方式 GB/T 7714 | Jiang Ruwei,Du Xiaoguang,Zhang Xuan,et al. synthesisandbioassayof14dmannansaspotentialagentsagainstalzheimersdisease[J]. actapharmacologicasinica,2013,34(12):1585. |
| APA | Jiang Ruwei.,Du Xiaoguang.,Zhang Xuan.,Wang Xin.,Hu Dingyu.,...&Shen Jingkang.(2013).synthesisandbioassayof14dmannansaspotentialagentsagainstalzheimersdisease.actapharmacologicasinica,34(12),1585. |
| MLA | Jiang Ruwei,et al."synthesisandbioassayof14dmannansaspotentialagentsagainstalzheimersdisease".actapharmacologicasinica 34.12(2013):1585. |
入库方式： OAI收割
来源：上海药物研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。