improvedsurvivalofporcineacuteliverfailurebyabioartificialliverdeviceimplantedwithinducedhumanfunctionalhepatocytes
文献类型：期刊论文
| 作者 | Shi Xiaolei1; Gao Yimeng2; Yan Yupeng2; Ma Hucheng1; Sun Lulu2; Huang Pengyu2; Ni Xuan3; Zhang Ludi2; Zhao Xin1; Ren Haozhen1 |
| 刊名 | cellresearch
 |
| 出版日期 | 2016 |
| 卷号 | 26期号:2页码:206 |
| ISSN号 | 1001-0602 |
| 关键词 | IN-VITRO EVALUATION SUPPORT-SYSTEM CONTROLLED-TRIAL ASSIST DEVICE CELLS TRANSPLANTATION PRESERVATION REVERSAL SAFETY acute liver failure functional hepatocytes bioartificial liver |
| DOI | 10.1038/cr.2016.6 |
| 英文摘要 | Acute liver failure (ALF) is a life-threatening illness. The extracorporeal cell-based bioartificial liver (BAL) system could bridge liver transplantation and facilitate liver regeneration for ALF patients by providing metabolic detoxification and synthetic functions. Previous BAL systems, based on hepatoma cells and non-human hepatocytes, achieved limited clinical advances, largely due to poor hepatic functions, cumbersome preparation or safety concerns of these cells. We previously generated human functional hepatocytes by lineage conversion (hiHeps). Here, by improving functional maturity of hiHeps and producing hiHeps at clinical scales (3 billion cells), we developed a hiHep-based BAL system (hiHep-BAL). In a porcine ALF model, hiHep-BAL treatment restored liver functions, corrected blood levels of ammonia and bilirubin, and prolonged survival. Importantly, human albumin and alpha-1-antitrypsin were detectable in hiHep-BAL-treated ALF pigs. Moreover, hiHep-BAL treatment led to attenuated liver damage, resolved inflammation and enhanced liver regeneration. Our findings indicate a promising clinical application of the hiHep-BAL system. |
| 资助项目 | ["Strategic Priority Research Program" of CAS] ; [National Natural Science Foundation of China (NSFC)] ; [Ministry of Science and Technology of China (MOST)] ; [Science and Technology Commission of Shanghai Municipality (STCSM)] ; [NSFC] ; [Natural Science Foundation of Jiangsu Province] ; [MOST] ; [Fudan Foundation] ; [STCSM] |
| 语种 | 英语 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/283136]  |
| 专题 | 中国科学院上海药物研究所 |
| 作者单位 | 1.南京大学 2.中国科学院上海生命科学研究院 3.中国科学院上海药物研究所 4.华东理工大学 5.复旦大学 |
| 推荐引用方式 GB/T 7714 | Shi Xiaolei,Gao Yimeng,Yan Yupeng,et al. improvedsurvivalofporcineacuteliverfailurebyabioartificialliverdeviceimplantedwithinducedhumanfunctionalhepatocytes[J]. cellresearch,2016,26(2):206. |
| APA | Shi Xiaolei.,Gao Yimeng.,Yan Yupeng.,Ma Hucheng.,Sun Lulu.,...&Hui Lijian.(2016).improvedsurvivalofporcineacuteliverfailurebyabioartificialliverdeviceimplantedwithinducedhumanfunctionalhepatocytes.cellresearch,26(2),206. |
| MLA | Shi Xiaolei,et al."improvedsurvivalofporcineacuteliverfailurebyabioartificialliverdeviceimplantedwithinducedhumanfunctionalhepatocytes".cellresearch 26.2(2016):206. |
入库方式： OAI收割
来源：上海药物研究所
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