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amyloidbetastructurebiologyandstructurebasedtherapeuticdevelopment
文献类型：期刊论文
| 作者 | Chen Guofang1; Xu Tinghai1; Yan Yan1; Zhou Yuren1; Jiang Yi1 ; Melcher Karsten2; Xu H Eric1
|
| 刊名 | actapharmacologicasinica
 |
| 出版日期 | 2017 |
| 卷号 | 38期号:9页码:1205 |
| 关键词 | BLOOD-BRAIN-BARRIER INSULIN-DEGRADING ENZYME SOLID-STATE NMR NICOTINIC ACETYLCHOLINE-RECEPTORS METABOTROPIC GLUTAMATE RECEPTORS ATOMIC-FORCE MICROSCOPY GAMMA-SECRETASE COMPLEX SMOOTH-MUSCLE-CELLS AMELIORATES MEMORY IMPAIRMENT ENDOTHELIN-CONVERTING ENZYME amyloid beta peptide amyloid precursor protein Alzheimer's disease neurodegenerative diseases drug discovery |
| ISSN号 | 1671-4083 |
| DOI | 10.1038/aps.2017.28 |
| 英文摘要 | Amyloid beta peptide (A beta) is produced through the proteolytic processing of a transmembrane protein, amyloid precursor protein (APP), by beta- and gamma-secretases. A beta accumulation in the brain is proposed to be an early toxic event in the pathogenesis of Alzheimer's disease, which is the most common form of dementia associated with plaques and tangles in the brain. Currently, it is unclear what the physiological and pathological forms of A beta are and by what mechanism A beta causes dementia. Moreover, there are no efficient drugs to stop or reverse the progression of Alzheimer's disease. In this paper, we review the structures, biological functions, and neurotoxicity role of A beta. We also discuss the potential receptors that interact with A beta and mediate A beta intake, clearance, and metabolism. Additionally, we summarize the therapeutic developments and recent advances of different strategies for treating Alzheimer's disease. Finally, we will report on the progress in searching for novel, potentially effective agents as well as selected promising strategies for the treatment of Alzheimer's disease. These prospects include agents acting on A beta, its receptors and tau protein, such as small molecules, vaccines and antibodies against A beta; inhibitors or modulators of beta- and beta-secretase; A beta-degrading proteases; tau protein inhibitors and vaccines; amyloid dyes and microRNAs. |
| 资助项目 | [Postdoctoral Science Foundation of China] ; [National Natural Science Foundation of China] ; [Shanghai Science and Technology Committee] ; [Jay and Betty Van Andel Foundation, Amway (China)] ; [Ministry of Science and Technology of China] |
| 语种 | 英语 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/283250]  |
| 专题 | 中国科学院上海药物研究所 |
| 作者单位 | 1.中国科学院上海药物研究所 2.Laboratory of Structural Sciences, Van Andel Research Institute |
| 推荐引用方式 GB/T 7714 | Chen Guofang,Xu Tinghai,Yan Yan,et al. amyloidbetastructurebiologyandstructurebasedtherapeuticdevelopment[J]. actapharmacologicasinica,2017,38(9):1205. |
| APA | Chen Guofang.,Xu Tinghai.,Yan Yan.,Zhou Yuren.,Jiang Yi.,...&Xu H Eric.(2017).amyloidbetastructurebiologyandstructurebasedtherapeuticdevelopment.actapharmacologicasinica,38(9),1205. |
| MLA | Chen Guofang,et al."amyloidbetastructurebiologyandstructurebasedtherapeuticdevelopment".actapharmacologicasinica 38.9(2017):1205. |
入库方式： OAI收割
来源：上海药物研究所
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