myd88independentactivationofanovelactincdc42racpathwayisrequiredfortolllikereceptorstimulatedphagocytosis
文献类型：期刊论文
| 作者 | Kong Ling1; Ge BaoXue1 |
| 刊名 | cellresearch
 |
| 出版日期 | 2008 |
| 卷号 | 18期号:7页码:745 |
| 关键词 | SIGNAL-REGULATED KINASE PROTEIN-KINASE PHAGOSOME MATURATION INNATE IMMUNITY RHO GTPASES P38 LIPOPOLYSACCHARIDE TRANSDUCTION MACROPHAGES RECOGNITION innate immunity Toll-like receptors phagocytosis GTPases actin p38 |
| ISSN号 | 1001-0602 |
| DOI | 10.1038/cr.2008.65 |
| 英文摘要 | Phagocytosis and subsequent degradation of pathogens by macrophages play a pivotal role in host innate immune responses to microbial infection. Recent studies have shown that Toll-like receptors (TLRs) play an important role in promoting the clearance of bacteria by up-regulating the phagocytic activity of macrophages. However, information regarding the signaling mechanism of TLR-mediated phagocytosis is still limited. Here, we provide evidence that the stimulation of TLR4 with LPS leads to activation of multiple signaling pathways including MAP kinases, phosphatidylinositide 3-kinase (PI3K), and small GTPases in the murine macrophage-like cell line RAW264.7. Specific inhibition of Cdc42/Rac or P38 MAP kinase, but not PI3K, reduced TLR4-induced phagocytosis of bacteria. Moreover, we have found that either inhibition of actin polymerization by cytochalasin D or the knockdown of actin by RNAi markedly reduced the activation of Cdc42 and Rac by LPS. TLR4-induced activation of Cdc42 and Rac appears to be independent of MyD88. Taken together, our results described a novel actin-Cdc42/Rac pathway through which TLRs can specifically provoke phagocytosis. |
| 语种 | 英语 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/283478]  |
| 专题 | 中国科学院上海药物研究所 |
| 作者单位 | 1.中国科学院上海药物研究所 2.上海交通大学医学院 3.中国科学院 |
| 推荐引用方式 GB/T 7714 | Kong Ling,Ge BaoXue. myd88independentactivationofanovelactincdc42racpathwayisrequiredfortolllikereceptorstimulatedphagocytosis[J]. cellresearch,2008,18(7):745. |
| APA | Kong Ling,&Ge BaoXue.(2008).myd88independentactivationofanovelactincdc42racpathwayisrequiredfortolllikereceptorstimulatedphagocytosis.cellresearch,18(7),745. |
| MLA | Kong Ling,et al."myd88independentactivationofanovelactincdc42racpathwayisrequiredfortolllikereceptorstimulatedphagocytosis".cellresearch 18.7(2008):745. |
入库方式： OAI收割
来源：上海药物研究所
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