targetingerkanachillesheelofthemapkpathwayincancertherapy
文献类型：期刊论文
| 作者 | Liu Feifei; Yang Xiaotong; Geng Meiyu ; Huang Min
|
| 刊名 | actapharmaceuticasinicab
 |
| 出版日期 | 2018 |
| 卷号 | 8期号:4页码:552 |
| 关键词 | Mitogen-activated protein kinases Extracellular signal-regu lated kinase ERK inhibitor ERK kinase Cancer therapy Drug resistance |
| ISSN号 | 2211-3835 |
| DOI | 10.1016/j.apsb.2018.01.008 |
| 英文摘要 | The mitogen-activated protein kinases (MAPK) pathway, often known as the RAS-RAFMEK-ERK signal cascade, functions to transmit upstream signals to its downstream effectors to regulate physiological process such as cell proliferation, differentiation, survival and death. As the most frequently mutated signaling pathway in human cancer, targeting the MAPK pathway has long been considered a promising strategy for cancer therapy. Substantial efforts in the past decades have led to the clinical success of BRAF and MEK inhibitors. However, the clinical benefits of these inhibitors are compromised by the frequently occurring acquired resistance due to cancer heterogeneity and genomic instability. This review briefly introduces the key protein kinases involved in this pathway as well as their activation mechanisms. We also generalize the correlations between mutations of MAPK members and human cancers, followed by a summarization of progress made on the development of small molecule MAPK kinases inhibitors. In particular, this review highlights the potential advantages of ERK inhibitors in overcoming resistance to upstream targets and proposes that targeting ERK kinase may hold a promising prospect for cancer therapy. |
| 语种 | 英语 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/283492]  |
| 专题 | 中国科学院上海药物研究所 |
| 作者单位 | 中国科学院上海药物研究所 |
| 推荐引用方式 GB/T 7714 | Liu Feifei,Yang Xiaotong,Geng Meiyu,et al. targetingerkanachillesheelofthemapkpathwayincancertherapy[J]. actapharmaceuticasinicab,2018,8(4):552. |
| APA | Liu Feifei,Yang Xiaotong,Geng Meiyu,&Huang Min.(2018).targetingerkanachillesheelofthemapkpathwayincancertherapy.actapharmaceuticasinicab,8(4),552. |
| MLA | Liu Feifei,et al."targetingerkanachillesheelofthemapkpathwayincancertherapy".actapharmaceuticasinicab 8.4(2018):552. |
入库方式： OAI收割
来源：上海药物研究所
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