artemisininanaloguesm934amelioratesdssinducedmouseulcerativecolitisviasuppressingneutrophilsandmacrophages
文献类型：期刊论文
| 作者 | Yan Yuxi1; Shao Meijuan2; Qi Qing1; Xu Yansheng2; Yang Xiaoqian1; Zhu Fenghua1; He Shijun1 ; He Peilan1; Feng Chunian1; Wu Yanwei1
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| 刊名 | actapharmacologicasinica
 |
| 出版日期 | 2018 |
| 卷号 | 39期号:10页码:1633 |
| 关键词 | NF-KAPPA-B SODIUM-INDUCED COLITIS MURINE COLITIS MICE CYTOKINES CELLS SM934 artemisinin analogue ulcerative colitis inflammatory bowel disease (IBD) neutrophils macrophage NF-kappa B RAW 2647 cells THP-1-derived macrophages |
| ISSN号 | 1671-4083 |
| DOI | 10.1038/aps.2017.185 |
| 英文摘要 | Ulcerative colitis (UC) is a chronic, nonspecific inflammatory bowel disease (IBD) characterized by complicated and relapsing inflammation in the gastrointestinal tract. SM934 is a water-soluble artemisinin analogue that shows anti-inflammatory and immuno-regulatory effects. In this study, we investigated the effects of SM934 on UC both in vivo and in vitro. A mouse model of colitis was established in mice by oral administration of 5% dextran sulfate sodium (DSS). SM934 (3, 10 mg/kg per day, ig) was administered to the mice for 10 days. After the mice were sacrificed, colons, spleens and mesenteric lymph nodes (MLNs) were collected for analyses. SM934 administration restored DSS-induced body weight loss, colon shortening, injury and inflammation scores. Furthermore, SM934 administration significantly decreased the disease activity index (DAI), histopathological scores, and myeloperoxidase (MPO) activities in colonic tissues. Moreover, SM934 administration dose-dependently decreased the mRNA and protein levels of DSS-induced pro-inflammatory cytokines (IL-1 beta, IL-6 and TNF-alpha), and the percentage of macrophages and neutrophils in colon tissues. The effects of SM934 on LPS-stimulated RAW 264.7 cells and THP-1-derived macrophages were examined in vitro. Treatment with SM934 (0.8, 8, 80 mu mol/L) dose-dependently decreased the production of pro-inflammatory mediators in LPS-stimulated RAW 264.7 cells and THP-1-derived macrophages via inhibiting activation of the NF-kappa B signaling. Our results reveal the protective effects of SM934 on DSS-induced colitis can be attributed to its suppressing effects on neutrophils and macrophages and its inhibitory role in the NF-kappa B signaling, suggests that SM934 might be a potential effective drug for ulcerative colitis. |
| 资助项目 | ["Personalized Medicines Molecular Signature-based Drug Discovery and Development", Strategic Priority Research Program of the Chinese Academy of Sciences] ; [National Science & Technology Major Project "New Drug Creation and Manufacturing Program", China] ; [National Natural Science Foundation of China (NSFC)] |
| 语种 | 英语 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/283497]  |
| 专题 | 中国科学院上海药物研究所 |
| 作者单位 | 1.中国科学院上海药物研究所 2.Laboratory of Immunology and Virology,Shanghai University of Traditional Chinese Medicine |
| 推荐引用方式 GB/T 7714 | Yan Yuxi,Shao Meijuan,Qi Qing,et al. artemisininanaloguesm934amelioratesdssinducedmouseulcerativecolitisviasuppressingneutrophilsandmacrophages[J]. actapharmacologicasinica,2018,39(10):1633. |
| APA | Yan Yuxi.,Shao Meijuan.,Qi Qing.,Xu Yansheng.,Yang Xiaoqian.,...&Zuo Jianping.(2018).artemisininanaloguesm934amelioratesdssinducedmouseulcerativecolitisviasuppressingneutrophilsandmacrophages.actapharmacologicasinica,39(10),1633. |
| MLA | Yan Yuxi,et al."artemisininanaloguesm934amelioratesdssinducedmouseulcerativecolitisviasuppressingneutrophilsandmacrophages".actapharmacologicasinica 39.10(2018):1633. |
入库方式： OAI收割
来源：上海药物研究所
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