interactionsofacetylcholinesterasewithsalvianolicacidbandrosmarinicacidfromsalviamiltiorhizawaterextractinvestigatedbynmrrelaxationrate
文献类型：期刊论文
| 作者 | Guo WeiYin2; Yi MingLi3; Wei Wei2; Shan HaoJiang1; Da YuanZhu1; Wei HongDu2 |
| 刊名 | chinesechemicalletters
 |
| 出版日期 | 2008 |
| 卷号 | 19期号:6页码:747 |
| 关键词 | HUMAN SERUM-ALBUMIN INHIBITORS H-1-NMR AChE inhibitors Salvianolic acid B Rosmarinic acid NMR relaxation rate |
| ISSN号 | 1001-8417 |
| DOI | 10.1016/j.cclet.2008.04.013 |
| 英文摘要 | In order to understand whether the ameliorating effect on old ages memory disorder by the root of Salvia miltiorhiza is related to the acetylcholinesterase (AChE) inhibition, two main ingredients, salvianolic acid B ( 1) and rosmarinic acid ( 2), which were isolated from S. miltiorhiza water extract, were investigated in vitro by NMR relaxation rate in this work. The results showed that the proton selective relaxation rates and the molecular rotational correlation time of proton pairs for compounds 1 and 2 increased significantly by adding of AChE in mixing solution. The study reveals that the two compounds might bind to the enzyme and have AChE inhibitory effect, which could contribute to the ameliorating effect at some extent on old ages memory disorder. (c) 2008 Wei Hong Du. Published by Elsevier B. V. on behalf of Chinese Chemical Society. All rights reserved. |
| 资助项目 | [National Natural Science Foundation of China] |
| 语种 | 英语 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/283504]  |
| 专题 | 中国科学院上海药物研究所 |
| 作者单位 | 1.中国科学院上海药物研究所 2.中国人民大学 3.上海中医药大学 |
| 推荐引用方式 GB/T 7714 | Guo WeiYin,Yi MingLi,Wei Wei,et al. interactionsofacetylcholinesterasewithsalvianolicacidbandrosmarinicacidfromsalviamiltiorhizawaterextractinvestigatedbynmrrelaxationrate[J]. chinesechemicalletters,2008,19(6):747. |
| APA | Guo WeiYin,Yi MingLi,Wei Wei,Shan HaoJiang,Da YuanZhu,&Wei HongDu.(2008).interactionsofacetylcholinesterasewithsalvianolicacidbandrosmarinicacidfromsalviamiltiorhizawaterextractinvestigatedbynmrrelaxationrate.chinesechemicalletters,19(6),747. |
| MLA | Guo WeiYin,et al."interactionsofacetylcholinesterasewithsalvianolicacidbandrosmarinicacidfromsalviamiltiorhizawaterextractinvestigatedbynmrrelaxationrate".chinesechemicalletters 19.6(2008):747. |
入库方式： OAI收割
来源：上海药物研究所
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