anewsyntheticmethodofnaturalproducttrichostatina
文献类型：期刊论文
| 作者 | Zhao X(赵曦); Zhang SL(张士磊); Duan WH(段文虎)
|
| 刊名 | chinesejournaloforganicchemistry
 |
| 出版日期 | 2007 |
| 卷号 | 27期号:12页码:1509 |
| 关键词 | HISTONE DEACETYLASE INHIBITORS FRIEND LEUKEMIC-CELLS POTENT DIFFERENTIATION ENZYME trichostatin A histone deacetylase inhibitor L-proline synthesis |
| ISSN号 | 0253-2786 |
| 英文摘要 | An efficient synthesis of trichostatin A, A potent histone deacetylase inhibitor, was reported. The key point in this new approach lied in the highly stereocontrolled establishment of its chiral center using L-proline-catalyzed aldol reaction between p-nitrobenzaldehyde and propaidehyde. The aldol product was obtained with >99% ee and high de (anti : syn =16 : 1). No racemization was found in the following process and the synthetic trichostatin A was a pure R enantiomer with more than 99% ee. |
| 语种 | 英语 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/283632]  |
| 专题 | 中国科学院上海药物研究所 |
| 作者单位 | 中国科学院上海药物研究所 |
| 推荐引用方式 GB/T 7714 | Zhao X,Zhang SL,Duan WH. anewsyntheticmethodofnaturalproducttrichostatina[J]. chinesejournaloforganicchemistry,2007,27(12):1509. |
| APA | 赵曦,张士磊,&段文虎.(2007).anewsyntheticmethodofnaturalproducttrichostatina.chinesejournaloforganicchemistry,27(12),1509. |
| MLA | 赵曦,et al."anewsyntheticmethodofnaturalproducttrichostatina".chinesejournaloforganicchemistry 27.12(2007):1509. |
入库方式： OAI收割
来源：上海药物研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。