designsynthesisandinvitroevaluationofmono222trifluoroethylestersmonolaminoacidesterprodrugsofacyclicnucleosidephosphonatesasantihbvagents
文献类型：期刊论文
| 作者 | Fu Xiaozhong1; Ou Yu1; Xin Jan2; Yang Yushe3
|
| 刊名 | chinesechemicalletters
 |
| 出版日期 | 2011 |
| 卷号 | 22期号:12页码:1387 |
| 关键词 | CHRONIC HEPATITIS-B INTRACELLULAR DELIVERY DERIVATIVES MCC-478 VIRUS PMEA Acyclic nucleoside phosphonates L-Amino acid Prodrug |
| ISSN号 | 1001-8417 |
| DOI | 10.1016/j.cclet.2011.09.005 |
| 英文摘要 | A series of novel mono (2, 2, 2-trifluoroethyl) esters, mono L-amino acid ester prodrugs of acyclic nucleoside phosphonates was synthesized and their in vitro anti-HBVactivity was evaluated in HepG 2 2.2.15 cells. Compound 1d exhibited more potent anti-HBV activity and lower cytotoxicity than those of adefovir dipivoxil and alamifovir (MCC-478) with EC(50) and CC(50) values of 0.01 mu mol/L and >8000 mu mol/L respectively. (C) 2011 Yu She Yang. Published by Elsevier B.V. on behalf of Chinese Chemical Society. All rights reserved. |
| 资助项目 | [National Natural Science Foundation of China] ; [Provincial Social Development Foundation of Guizhou, China] ; [Provincial Special Assistant Foundation for High-level Talents of Guizhou, China] ; [Science and Technology Foundation of Guizhou Province, China] |
| 语种 | 英语 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/283721]  |
| 专题 | 中国科学院上海药物研究所 |
| 作者单位 | 1.School of Pharmacy, Guiyang Medical College 2.Shanghai Fudan-Yueda Bio-Tech Co., Ltd. 3.中国科学院上海药物研究所 |
| 推荐引用方式 GB/T 7714 | Fu Xiaozhong,Ou Yu,Xin Jan,et al. designsynthesisandinvitroevaluationofmono222trifluoroethylestersmonolaminoacidesterprodrugsofacyclicnucleosidephosphonatesasantihbvagents[J]. chinesechemicalletters,2011,22(12):1387. |
| APA | Fu Xiaozhong,Ou Yu,Xin Jan,&Yang Yushe.(2011).designsynthesisandinvitroevaluationofmono222trifluoroethylestersmonolaminoacidesterprodrugsofacyclicnucleosidephosphonatesasantihbvagents.chinesechemicalletters,22(12),1387. |
| MLA | Fu Xiaozhong,et al."designsynthesisandinvitroevaluationofmono222trifluoroethylestersmonolaminoacidesterprodrugsofacyclicnucleosidephosphonatesasantihbvagents".chinesechemicalletters 22.12(2011):1387. |
入库方式： OAI收割
来源：上海药物研究所
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