aspecificcholesterolmetabolicpathwayisestablishedinasubsetofhccsfortumorgrowth
文献类型：期刊论文
| 作者 | Lu Ming2; Hu Xihan2; Li Qin2; Xiong Ying2; Hu Guangjing2; Xu Jiajia2; Zhao Xiaonan2; Wei Xixiao2; Chang Catherine C Y1; Liu Yinkun3 |
| 刊名 | journalofmolecularcellbiology
 |
| 出版日期 | 2013 |
| 卷号 | 5期号:6页码:404 |
| 关键词 | ACAT2 CpG methylation oxysterol secretion inhibition of tumor growth HCC |
| ISSN号 | 1674-2788 |
| 英文摘要 | The liver plays a central role in cholesterol homeostasis. It exclusively receives and metabolizes oxysterols, which are important metabolites of cholesterol and are more cytotoxic than free cholesterol, from all extrahepatic tissues. Hepatocellular carcinomas (HCCs) impair certain liver functions and cause pathological alterations in many processes including cholesterol metabolism. However, the link between an altered cholesterol metabolism and HCC development is unclear. Human ACAT2 is abundantly expressed in intestine and fetal liver. Our previous studies have shown that ACAT2 is induced in certain HCC tissues. Here, by investigating tissue samples from HCC patients and HCC cell lines, we report that a specific cholesterol metabolic pathway, involving induction of ACAT2 and esterification of excess oxysterols for secretion to avoid cytotoxicity, is established in a subset of HCCs for tumor growth. Inhibiting ACAT2 leads to the intracellular accumulation of unesterified oxysterols and suppresses the growth of both HCC cell lines and their xenograft tumors. Further mechanistic studies reveal that HCC-linked promoter hypomethylation is essential for the induction of ACAT2 gene expression. We postulate that specifically blocking this HCC-established cholesterol metabolic pathway may have potential therapeutic applications for HCC patients. |
| 语种 | 英语 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/283793]  |
| 专题 | 中国科学院上海药物研究所 |
| 作者单位 | 1.Department of Biochemistry, Geisel School of Medicine at Dartmouth 2.中国科学院上海生命科学研究院 3.复旦大学 4.中国科学院上海药物研究所 |
| 推荐引用方式 GB/T 7714 | Lu Ming,Hu Xihan,Li Qin,et al. aspecificcholesterolmetabolicpathwayisestablishedinasubsetofhccsfortumorgrowth[J]. journalofmolecularcellbiology,2013,5(6):404. |
| APA | Lu Ming.,Hu Xihan.,Li Qin.,Xiong Ying.,Hu Guangjing.,...&Li Boliang.(2013).aspecificcholesterolmetabolicpathwayisestablishedinasubsetofhccsfortumorgrowth.journalofmolecularcellbiology,5(6),404. |
| MLA | Lu Ming,et al."aspecificcholesterolmetabolicpathwayisestablishedinasubsetofhccsfortumorgrowth".journalofmolecularcellbiology 5.6(2013):404. |
入库方式： OAI收割
来源：上海药物研究所
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