synthesesof15r16r19r20s34sand15s16s19s20r34sazasolamin
文献类型：期刊论文
| 作者 | Wang M(王猛); Shen JK(沈竞康) |
| 刊名 | chemicaljournalofchineseuniversitieschinese
 |
| 出版日期 | 2006 |
| 卷号 | 27期号:12页码:2324 |
| 关键词 | MITOCHONDRIAL COMPLEX-I ANNONACEOUS ACETOGENINS POTENT ANTITUMOR RECENT PROGRESS ANALOG DERIVATIVES INHIBITORS FRAGMENT MIMICRY CHAIN aza-solamin Annonaceous acetogenin coupling reaction |
| ISSN号 | 0251-0790 |
| 英文摘要 | A convergent synthesis of two possible diastereomers of aza-solamin (threo-trans-erythro) (2a and 2b), which possessed pyrrolidine ring in place of THF ring of solamm, was accomplished. The key building block 5a and 9a were originated from chrial starting material. The stereochemistry of pyrrolidine core unit was determined by H-1 NMR spectroscopic analysis. The preliminary results of in vitro test against A-549 and HCT-116 cell lines show that both compounds have almost the same activity. |
| 语种 | 英语 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/283864]  |
| 专题 | 中国科学院上海药物研究所 |
| 作者单位 | 中国科学院上海药物研究所 |
| 推荐引用方式 GB/T 7714 | Wang M,Shen JK. synthesesof15r16r19r20s34sand15s16s19s20r34sazasolamin[J]. chemicaljournalofchineseuniversitieschinese,2006,27(12):2324. |
| APA | 王猛,&沈竞康.(2006).synthesesof15r16r19r20s34sand15s16s19s20r34sazasolamin.chemicaljournalofchineseuniversitieschinese,27(12),2324. |
| MLA | 王猛,et al."synthesesof15r16r19r20s34sand15s16s19s20r34sazasolamin".chemicaljournalofchineseuniversitieschinese 27.12(2006):2324. |
入库方式： OAI收割
来源：上海药物研究所
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