protectiveeffectofraloxifeneonlipopolysaccharideandacidinducedacutelunginjuryinrats
文献类型：期刊论文
| 作者 | Guanyu JIANG1; Guangju ZHOU1; Hong ZHANG1; Shengde ZHI2; Guoping JIANG1; Jing WANG1; Mao ZHANG1; Jianxin GAN1; Shaowen XU1 |
| 刊名 | actapharmacologicasinica
 |
| 出版日期 | 2007 |
| 卷号 | 28期号:10页码:1585 |
| 关键词 | ACUTE RESPIRATORY-DISTRESS TOLL-LIKE RECEPTOR-4 HEMORRHAGIC-SHOCK FDG-PET INFLAMMATION ESTROGEN EXPRESSION INFECTION LEUKOCYTES PATTERN acute lung injury aspiration fluorodeoxy-glucose lipopolysaccharide microPET pulmonary edema raloxifene |
| ISSN号 | 1671-4083 |
| DOI | 10.1111/j.1745-7254.2007.00637.x |
| 英文摘要 | Aim: To evaluate the protective effect of oral raloxifene on acute lung injury. Methods: Thirty adult, male Sprague-Dawley rats each weighing 180-210 g were used and divided into 3 groups: the raloxifene-lipopolysaccharide (LPS)-HCl group (n=10), the LPS-raloxifene-HCl group (n=10), and the placebo group (n=10). All the rats were injected intraperitoneally (ip) with 5 mg/kg LPS, and raloxifene (30 mg/kg) was orally administered 1 h before and 14 h after LPS injection into the raloxifene-LPS-HCl and the LPS-raloxifene-HCl groups, respectively; the placebo group received nothing. Sixteen hours after LPS injection, all the animals were anesthetized and the femoral artery was cannulated. All the rats received a direct intratracheal (IT) injection of HCl (pH 1.2; 0.5 mL/kg). The mean arterial pressure (MAP) and blood gas concentrations were measured. Fifteen rats (5 in each group, respectively) underwent a micro positron emission tomography (microPET) scan of the thorax 4 h after HCl instillation. The wet/dry (W/D) weight ratio determination and histopathological examination were also performed. Results: The rats in the LPS-raloxifene-HCl group had a lower F-18fluorodeoxyglucose uptake compared with the rats in the placebo group (4.67 +/- 1.33 vs 9.01 +/- 1.58, respectively, P < 0.01). The rats in the LPS-raloxifene-HCl group also had a lower histological lung injury score (8.20 +/- 1.23 vs 12.6 +/- 0.97, respectively, P < 0.01) and W/D weight ratio (5.335 +/- 0.198 vs 5.886 +/- 0.257, respectively, P < 0. 01) compared to the placebo group. The rats in this group also showed better pulmonary gas exchange and more stable mean arterial pressure (MAP) compared to the placebo group. Conclusion: Raloxifene provides a significant protective effect on acute lung injury in rats induced first by LPS ip injection and then by HCl IT instillation. |
| 语种 | 英语 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/283977]  |
| 专题 | 中国科学院上海药物研究所 |
| 作者单位 | 1.浙江大学 2.中国科学院上海药物研究所 |
| 推荐引用方式 GB/T 7714 | Guanyu JIANG,Guangju ZHOU,Hong ZHANG,et al. protectiveeffectofraloxifeneonlipopolysaccharideandacidinducedacutelunginjuryinrats[J]. actapharmacologicasinica,2007,28(10):1585. |
| APA | Guanyu JIANG.,Guangju ZHOU.,Hong ZHANG.,Shengde ZHI.,Guoping JIANG.,...&Shaowen XU.(2007).protectiveeffectofraloxifeneonlipopolysaccharideandacidinducedacutelunginjuryinrats.actapharmacologicasinica,28(10),1585. |
| MLA | Guanyu JIANG,et al."protectiveeffectofraloxifeneonlipopolysaccharideandacidinducedacutelunginjuryinrats".actapharmacologicasinica 28.10(2007):1585. |
入库方式： OAI收割
来源：上海药物研究所
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