acontinuedsagaofboc5thefirstnonpeptidicglucagonlikepeptide1receptoragonistwithinvivoactivities
文献类型：期刊论文
| 作者 | He Min1; Guan Ni1; Gao Weiwei1; Liu Qing1; Wu Xiaoyan1; Ma Dawei2; Zhong Dafang1 ; Ge Guangbo3; Li Chuan1; Chen Xiaoyan1
|
| 刊名 | actapharmacologicasinica
 |
| 出版日期 | 2012 |
| 卷号 | 33期号:2页码:148 |
| 关键词 | Type 2 diabetes Glucagon-like peptide-1 Non-peptidic agonist Boc5 G-protein coupled receptor |
| ISSN号 | 1671-4083 |
| 英文摘要 | Glucagon-like peptide-1 (GLP-1)-based therapy presents a promising option for treatingtype 2 diabetes. However, there are several limitations relative to the peptidic GLP-1mimetics currently on the market or under development. This concern has led to a continuedinterest in the search for non-peptidic agonists for GLP-1 receptor (GLP-1R). Here, webriefly review the discovery, characterization and current status of a novel class ofcyclobutane-derivative-based non-peptidic agonists for GLP-1R, including Boc5 and itsnewly discovered analogue WB4–24. Although the oral bioavailability of suchcompounds still poses great challenges, the progress made so far encourages us to identifya truly 'druggable' small molecule agonist for GLP-1R. |
| 语种 | 英语 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/284094]  |
| 专题 | 中国科学院上海药物研究所 |
| 作者单位 | 1.中国科学院上海药物研究所 2.中国科学院上海有机化学研究所 3.中国科学院大连化学物理研究所 |
| 推荐引用方式 GB/T 7714 | He Min,Guan Ni,Gao Weiwei,et al. acontinuedsagaofboc5thefirstnonpeptidicglucagonlikepeptide1receptoragonistwithinvivoactivities[J]. actapharmacologicasinica,2012,33(2):148. |
| APA | He Min.,Guan Ni.,Gao Weiwei.,Liu Qing.,Wu Xiaoyan.,...&Wang Mingwei.(2012).acontinuedsagaofboc5thefirstnonpeptidicglucagonlikepeptide1receptoragonistwithinvivoactivities.actapharmacologicasinica,33(2),148. |
| MLA | He Min,et al."acontinuedsagaofboc5thefirstnonpeptidicglucagonlikepeptide1receptoragonistwithinvivoactivities".actapharmacologicasinica 33.2(2012):148. |
入库方式： OAI收割
来源：上海药物研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。