pegylatedpolycyanoacrylatenanoparticlesassalvicinecarrierssynthesispreparationandinvitrocharacterization
文献类型：期刊论文
| 作者 | Pei Yuanying1; Li Yaping2 ; Zhou ZHaohui2; Yuan Weifang2; Gu Zhouhui2; Zhang Xianying2
|
| 刊名 | actapharmacologicasinica
 |
| 出版日期 | 2001 |
| 卷号 | 22期号:7页码:645 |
| 关键词 | AMPHIPHILIC COPOLYMER NANOSPHERES GLYCOL) polyethylene glycols poly (alkyl cyanoacrylate) nanoparticles salvicine |
| ISSN号 | 0253-9756 |
| 英文摘要 | AIM: To synthesized poly( methoxypolyethyleneglycol cyanoacrylate-co-n-hexadecyl cyanoacrylate)( PEGylated PHDCA) with polyethylene glycol (PEG, M-r = 5000), prepare PEGylated PHDCA and poly ( n-hexadecyl cyanoacrylate) (PHDCA) nanoparticles loading salvicine and determine their in vitro characterizations. METHODS: The structure of PEGylated PHDCA was determined with H-1-NMR, C-13-NMR and Fourier transform infrared spectrum (FTIR). Its molecular weight was determined by gel permeation chromatography (GPC). Nanoparticles were prepared by emulsion/solvent evaporation method. RESULTS: 1H-NMR, 13C-NMR, and FTIR were consistent with structure of PEGylated PHDCA, whose average molecular weight is 6680. Entrapment efficiency could be determined by high pressure liquid chromatography (HPLC) method without endogenous interference at the retention time of salvicine. The entrapment efficiency was 92.6 % for PEGylated PHDCA nanoparticles and 98.9 % for PHDCA nanoparticles. The nanoparticles size was about 250nm. The values of the zeta potential were obviously influenced by the composition of the copolymer. Compared with PHDCA nanoparticles (-23.1 mV), PEGylated PHDCA nanoparticles showed a low surface potential (- 9.6 mV). Salvicine release from nanoparticles showed an initial burst effect, then a plateau for an extended period, and finally sustained release phase. CONCLUSION: These results showed that the PEGylated PHDCA nanoparticles could be an effective carrier for salvicine delivery in the respect of anti-tumor potency. |
| 语种 | 英语 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/284294]  |
| 专题 | 中国科学院上海药物研究所 |
| 作者单位 | 1.复旦大学 2.中国科学院上海药物研究所 |
| 推荐引用方式 GB/T 7714 | Pei Yuanying,Li Yaping,Zhou ZHaohui,et al. pegylatedpolycyanoacrylatenanoparticlesassalvicinecarrierssynthesispreparationandinvitrocharacterization[J]. actapharmacologicasinica,2001,22(7):645. |
| APA | Pei Yuanying,Li Yaping,Zhou ZHaohui,Yuan Weifang,Gu Zhouhui,&Zhang Xianying.(2001).pegylatedpolycyanoacrylatenanoparticlesassalvicinecarrierssynthesispreparationandinvitrocharacterization.actapharmacologicasinica,22(7),645. |
| MLA | Pei Yuanying,et al."pegylatedpolycyanoacrylatenanoparticlesassalvicinecarrierssynthesispreparationandinvitrocharacterization".actapharmacologicasinica 22.7(2001):645. |
入库方式： OAI收割
来源：上海药物研究所
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