synthesispharmacokineticsandinvivoantifungalactivityofthenovelwatersolubleprodrugsofitraconazoleanalogueyl24
文献类型：期刊论文
| 作者 | Liu Yu1; Cao Xufeng1; Liu Xin1; Cao Yongbing2; Chu Wenjing1; Yang Yushe1
|
| 刊名 | chinesechemicalletters
 |
| 出版日期 | 2013 |
| 卷号 | 24期号:4页码:321 |
| 关键词 | DERIVATIVES SPECTRUM DESIGN AGENT Synthesis Antifungal Water-soluble prodrugs Itraconazole analogue |
| ISSN号 | 1001-8417 |
| DOI | 10.1016/j.cclet.2013.03.008 |
| 英文摘要 | To improve the aqueous solubility of an itraconazole analogue, compound 1 (YL-24), a series of novel prodrugs were synthesized. Among these prodrugs, the phosphate disodium salt compound 7 exhibited excellent aqueous solubility (9.8 mg/mL) at near-neutral pH and sufficient stability in buffer solutions, along with favorable pharmacokinetic profiles. In particular, compounds 1 and 7 provided moderate survival efficacy in murine systemic Candida albicans SC5314 infection model, but their efficacy was weaker than that of fluconazole. (C) 2013 Yu-She Yang. Published by Elsevier B.V. on behalf of Chinese Chemical Society. All rights reserved. |
| 资助项目 | [National Science and Technology Major Project] ; [Key New Drug Creation and Manufacturing Program, China] |
| 语种 | 英语 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/284336]  |
| 专题 | 中国科学院上海药物研究所 |
| 作者单位 | 1.中国科学院上海药物研究所 2.中国人民解放军第二军医大学 |
| 推荐引用方式 GB/T 7714 | Liu Yu,Cao Xufeng,Liu Xin,et al. synthesispharmacokineticsandinvivoantifungalactivityofthenovelwatersolubleprodrugsofitraconazoleanalogueyl24[J]. chinesechemicalletters,2013,24(4):321. |
| APA | Liu Yu,Cao Xufeng,Liu Xin,Cao Yongbing,Chu Wenjing,&Yang Yushe.(2013).synthesispharmacokineticsandinvivoantifungalactivityofthenovelwatersolubleprodrugsofitraconazoleanalogueyl24.chinesechemicalletters,24(4),321. |
| MLA | Liu Yu,et al."synthesispharmacokineticsandinvivoantifungalactivityofthenovelwatersolubleprodrugsofitraconazoleanalogueyl24".chinesechemicalletters 24.4(2013):321. |
入库方式： OAI收割
来源：上海药物研究所
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