improvedsynthesisofrupintrivir
文献类型：期刊论文
| 作者 | Lin Daizong1; Qian Wangke2; Hilgenfeld Rolf1; Jiang Hualiang1 ; Chen Kaixian1; Liu Hong1
|
| 刊名 | sciencechinachemistry
 |
| 出版日期 | 2012 |
| 卷号 | 55期号:6页码:1101 |
| 关键词 | RHINOVIRUS PROTEASE INHIBITOR STRUCTURE-BASED DESIGN BIOLOGICAL EVALUATION ENTEROVIRUS 71 INTERMEDIATE PROTEINASE EFFICIENT AG7088 rupintrivir AG7088 synthesis |
| ISSN号 | 1674-7291 |
| DOI | 10.1007/s11426-011-4478-5 |
| 英文摘要 | An improved synthesis of rupintrivir (AG7088) was accomplished using three amino acids (l-glutamic acid, d-4-fluorophenylalanine, and l-valine) as the building blocks. The key fragment ketomethylene dipeptide isostere was constructed with the valine derivative and phenylpropionic acid derivative, followed by coupling with a lactam derivative and an isoxazole acid chloride to provide AG7088 totally in eight steps. |
| 资助项目 | [National Natural Science Foundation of China] ; [National Basic Research Program of China] ; [Chinese Academy of Sciences] ; [European Commission] |
| 语种 | 英语 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/284800]  |
| 专题 | 中国科学院上海药物研究所 |
| 作者单位 | 1.中国科学院上海药物研究所 2.沈阳药科大学 |
| 推荐引用方式 GB/T 7714 | Lin Daizong,Qian Wangke,Hilgenfeld Rolf,et al. improvedsynthesisofrupintrivir[J]. sciencechinachemistry,2012,55(6):1101. |
| APA | Lin Daizong,Qian Wangke,Hilgenfeld Rolf,Jiang Hualiang,Chen Kaixian,&Liu Hong.(2012).improvedsynthesisofrupintrivir.sciencechinachemistry,55(6),1101. |
| MLA | Lin Daizong,et al."improvedsynthesisofrupintrivir".sciencechinachemistry 55.6(2012):1101. |
入库方式： OAI收割
来源：上海药物研究所
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