synthesisandproteintyrosinephosphatase1binhibitoryactivityevaluationofindolepropylbased134oxadiazolederivatives
文献类型：期刊论文
| 作者 | Mei WW(梅雯雯)1; Guo YW(郭跃伟)2 ; Li J(李佳)2; Cai MY(蔡妹艺)1; Ma WQ(马文泉)3; Gong JX(龚景旭)2; Wang XD(王学东)1
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| 刊名 | chinesejournaloforganicchemistry
 |
| 出版日期 | 2016 |
| 卷号 | 36期号:3页码:533 |
| 关键词 | MARINE NATURAL-PRODUCTS BIOLOGICAL EVALUATION LYCOGARUBIN C PHIDIANIDINES PROGRESS DESIGN DRUGS 1,3,4-oxadiazole synthesis PTP1B inhibitory activity |
| ISSN号 | 0253-2786 |
| DOI | 10.6023/cjoc201509024 |
| 英文摘要 | A series of indolepropyl based 1,3,4-oxadiazole derivatives were synthesized by esterification, hydrazidation, cyclization and substitution using indolebutyric acid as starting material. The inhibitory activity against protein tyrosine phosphatase 1B (PTP1B) was evaluated. The results indicated that five compounds displayed obviously inhibitory effect against PTP1B in vitro, for instance, compound 5g exhibited the strongest PTP1B inhibitory activity with an IC50 value of 6.74 mu g.mL(-1). It was the first example of indolealkyl based oxadiazole derivatives showing PTP1B inhibitory activity. |
| 资助项目 | [National Marine "863" Projects] ; [National Natural Science Foundation of China] ; [NSFC-Shandong Joint Fund for Marine Science Research Centers] ; [Science and Technology Commission of Shanghai Municipality Project] ; [State Key Laboratory of Drug Research/Shanghai Institute of Materia Medica Projects] |
| 语种 | 英语 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/284846]  |
| 专题 | 中国科学院上海药物研究所 |
| 作者单位 | 1.潍坊医学院 2.中国科学院上海药物研究所 3.潍坊生物医药创新创业服务中心 |
| 推荐引用方式 GB/T 7714 | Mei WW,Guo YW,Li J,et al. synthesisandproteintyrosinephosphatase1binhibitoryactivityevaluationofindolepropylbased134oxadiazolederivatives[J]. chinesejournaloforganicchemistry,2016,36(3):533. |
| APA | 梅雯雯.,郭跃伟.,李佳.,蔡妹艺.,马文泉.,...&王学东.(2016).synthesisandproteintyrosinephosphatase1binhibitoryactivityevaluationofindolepropylbased134oxadiazolederivatives.chinesejournaloforganicchemistry,36(3),533. |
| MLA | 梅雯雯,et al."synthesisandproteintyrosinephosphatase1binhibitoryactivityevaluationofindolepropylbased134oxadiazolederivatives".chinesejournaloforganicchemistry 36.3(2016):533. |
入库方式： OAI收割
来源：上海药物研究所
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