structureoftheprc2complexandapplicationtodrugdiscovery
文献类型：期刊论文
| 作者 | Shi Yi1 ; Wang Xiaoxi1; Zhuang Youwen1; Jiang Yi1; Melcher Karsten2; Xu H Eric1
|
| 刊名 | actapharmacologicasinica
 |
| 出版日期 | 2017 |
| 卷号 | 38期号:7页码:963 |
| 关键词 | PRC2 histone methyltransferase H3K27me3 nucleosome structure drug discovery |
| ISSN号 | 1671-4083 |
| DOI | 10.1038/aps.2017.7 |
| 英文摘要 | The polycomb repressive complexes 2 (PRC2) complex catalyzes tri-methylation of histone H3 lysine 27 (H3K27), a repressive chromatin marker associated with gene silencing. Overexpresslon and mutations of PRC2 are found in a wide variety of cancers, making the catalytic activity of PRC2 an important target of cancer therapy. This review highlights recent structural breakthroughs of the human PRC2 complex bound to the H3K27 peptide and a small molecule inhibitor, which provide critically needed insight Into PRC2-targeted drug discovery. |
| 语种 | 英语 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/284859]  |
| 专题 | 中国科学院上海药物研究所 |
| 作者单位 | 1.中国科学院上海药物研究所 2.Laboratory of Structural Sciences, Van Andel Research Institute |
| 推荐引用方式 GB/T 7714 | Shi Yi,Wang Xiaoxi,Zhuang Youwen,et al. structureoftheprc2complexandapplicationtodrugdiscovery[J]. actapharmacologicasinica,2017,38(7):963. |
| APA | Shi Yi,Wang Xiaoxi,Zhuang Youwen,Jiang Yi,Melcher Karsten,&Xu H Eric.(2017).structureoftheprc2complexandapplicationtodrugdiscovery.actapharmacologicasinica,38(7),963. |
| MLA | Shi Yi,et al."structureoftheprc2complexandapplicationtodrugdiscovery".actapharmacologicasinica 38.7(2017):963. |
入库方式： OAI收割
来源：上海药物研究所
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