aneweraforgpcrresearchstructuresbiologyanddrugdiscovery
文献类型：期刊论文
| 作者 | Xu H Eric1; Xiao Ruiping2 |
| 刊名 | actapharmacologicasinica
 |
| 出版日期 | 2012 |
| 卷号 | 33期号:3页码:289 |
| 关键词 | GPCR drug discovery Structure and Function of Drug Targets |
| ISSN号 | 1671-4083 |
| DOI | 10.1038/aps.2012.16 |
| 英文摘要 | Cells in a living organism must communicate with each other through continuously sending and receiving messages. G-protein coupled receptors (GPCRs) are the largest family of communicating molecules at the cell surface. They transmit diverse extracellular signals, ranging from light and small chemical hormones to large peptide and protein hormones, and as such they play crucial roles in numerous physiological and pathological processes. More importantly, GPCRs are the most successful class of drug targets that are relevant to many major diseases, including cancer, heart failure, and inflammatory diseases. Over 50% of currently used drugs are targeted to GPCRs. However, these drugs target only 50-60 GPCRs, leaving the majority of human GPCRs, exceeding 800, unexplored for drug discovery. Given the prominent roles of GPCRs in biology and their successful track records as drug targets, GPCRs have become a hot frontier in basic research of life science and therapeutic discovery of translational medicines. |
| 语种 | 英语 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/284873]  |
| 专题 | 中国科学院上海药物研究所 |
| 作者单位 | 1.中国科学院上海药物研究所 2.北京大学 |
| 推荐引用方式 GB/T 7714 | Xu H Eric,Xiao Ruiping. aneweraforgpcrresearchstructuresbiologyanddrugdiscovery[J]. actapharmacologicasinica,2012,33(3):289. |
| APA | Xu H Eric,&Xiao Ruiping.(2012).aneweraforgpcrresearchstructuresbiologyanddrugdiscovery.actapharmacologicasinica,33(3),289. |
| MLA | Xu H Eric,et al."aneweraforgpcrresearchstructuresbiologyanddrugdiscovery".actapharmacologicasinica 33.3(2012):289. |
入库方式： OAI收割
来源：上海药物研究所
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