designsynthesisandinvitroevaluationoflaminoacidestersprodrugsofacyclicnucleosidephosphonatesasantihbvagent
文献类型：期刊论文
| 作者 | Xiao ZhongFu1; Sai HongJiang2; Jian Xin3; Yu SheYang2; Ru YunJi2 |
| 刊名 | chinesechemicalletters
 |
| 出版日期 | 2007 |
| 卷号 | 18期号:7页码:817 |
| 关键词 | acyclic nucleoside phosphonates L-amino acid prodrug anti-HBV activity |
| ISSN号 | 1001-8417 |
| DOI | 10.1016/j.cclet.2007.05.013 |
| 英文摘要 | Aseries of novel L-amino acid esters prodrugs of acyclic nucleoside phosphonates was synthesized and their anti-HBV activity was evaluated in HepG2 2.2.15 cells. Compound 1d exhibited more potent anti-HBV activity and lower cytotoxicity than those of adefovir dipivoxil with EC50 and CC50 values of 0.207 mu mol/L and 2530 mu mol/L, respectively. (C) 2007 Yu She Yang. Published by Elsevier B.V. on behalf of Chinese Chemical Society. All rights reserved. |
| 语种 | 英语 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/284885]  |
| 专题 | 中国科学院上海药物研究所 |
| 作者单位 | 1.School of Pharmacy, Guiyang Medical College 2.中国科学院上海药物研究所 3.Shanghai Fudan-Yueda Bio-Tech Co. Ltd |
| 推荐引用方式 GB/T 7714 | Xiao ZhongFu,Sai HongJiang,Jian Xin,et al. designsynthesisandinvitroevaluationoflaminoacidestersprodrugsofacyclicnucleosidephosphonatesasantihbvagent[J]. chinesechemicalletters,2007,18(7):817. |
| APA | Xiao ZhongFu,Sai HongJiang,Jian Xin,Yu SheYang,&Ru YunJi.(2007).designsynthesisandinvitroevaluationoflaminoacidestersprodrugsofacyclicnucleosidephosphonatesasantihbvagent.chinesechemicalletters,18(7),817. |
| MLA | Xiao ZhongFu,et al."designsynthesisandinvitroevaluationoflaminoacidestersprodrugsofacyclicnucleosidephosphonatesasantihbvagent".chinesechemicalletters 18.7(2007):817. |
入库方式： OAI收割
来源：上海药物研究所
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