antibacterialsorbicillinanddiketopiperazinesfromtheendogenousfunguspenicilliumspgd6associatedchinesemangrovebruguieragymnorrhiza
文献类型：期刊论文
| 作者 | Jiang Chengshi1; Zhou Zhenfang1; Yang Xiaohong2; Lan Lefu1 ; Gu Yucheng3; Ye Boping2; Guo Yuewei1
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| 刊名 | chinesejournalofnaturalmedicines
 |
| 出版日期 | 2018 |
| 卷号 | 16期号:5页码:358 |
| ISSN号 | 2095-6975 |
| 关键词 | ANALOGS INHIBITORS DESIGN Mangrove Penicillium sp. Sorbicillin derivative Diketopiperazine alkaloids |
| 英文摘要 | One new sorbicillin derivative, 2-deoxy-sohirnone C (1), one new diketopiperazine alkaloid, 5S-hydroxynorvaline-S-Ile (2), and two naturally occurring diketopiperazines, 3S-hydroxylcyclo(S-Pro-S-Phe) (3) and cyclo(S-Phe-S-Gln) (4), together with three known compounds were isolated from the Chinese mangrove endophytic fungus Penicillium sp. GD6. Their structures were determined on the basis of extensive spectroscopic analyses and by comparison with literature data. The absolute configuration of 3-hydroxyl moiety in 3 was determined by Mosher's method, while the absolute stereochemistry of 2 and 4 was established by comparison with the CD spectra of natural and synthesized diketopiperazines. Compound 1 showed moderate antibacterial activity against Methicillin-resistant Staphylococcus aureus with a MIC value of 80 mu g.mL(-1). |
| 资助项目 | [Natural Science Foundation of China] ; [SCTSM Projects] ; [SKLDR/SIMM Project] |
| 语种 | 英语 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/284962]  |
| 专题 | 中国科学院上海药物研究所 |
| 作者单位 | 1.中国科学院上海药物研究所 2.中国药科大学 3.Syngenta Jealott's Hill International Research Centre |
| 推荐引用方式 GB/T 7714 | Jiang Chengshi,Zhou Zhenfang,Yang Xiaohong,et al. antibacterialsorbicillinanddiketopiperazinesfromtheendogenousfunguspenicilliumspgd6associatedchinesemangrovebruguieragymnorrhiza[J]. chinesejournalofnaturalmedicines,2018,16(5):358. |
| APA | Jiang Chengshi.,Zhou Zhenfang.,Yang Xiaohong.,Lan Lefu.,Gu Yucheng.,...&Guo Yuewei.(2018).antibacterialsorbicillinanddiketopiperazinesfromtheendogenousfunguspenicilliumspgd6associatedchinesemangrovebruguieragymnorrhiza.chinesejournalofnaturalmedicines,16(5),358. |
| MLA | Jiang Chengshi,et al."antibacterialsorbicillinanddiketopiperazinesfromtheendogenousfunguspenicilliumspgd6associatedchinesemangrovebruguieragymnorrhiza".chinesejournalofnaturalmedicines 16.5(2018):358. |
入库方式： OAI收割
来源：上海药物研究所
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