designsynthesisandbiologicalevaluationofacylhydrazonederivativesaspi3kinhibitors
文献类型：期刊论文
| 作者 | Gao Guorui1; Liu Jiali2; Mei Desheng3; Ding Jian2; Meng Linghua2; Duan Wenhu1 |
| 刊名 | chinesechemicalletters
 |
| 出版日期 | 2015 |
| 卷号 | 26期号:1页码:118 |
| 关键词 | PI3-KINASE P110-ALPHA INHIBITORS 3-KINASE PATHWAY PI3K Inhibitor Aclhydrazone |
| ISSN号 | 1001-8417 |
| DOI | 10.1016/j.cclet.2014.10.016 |
| 英文摘要 | Since the PI3K signaling pathway is the most commonly activated in human cancers, inhibition of PI3K K is a promising approach to cancer therapy. In this study, a series of 2-methyl-5-nitrobenzeneacylhydrazones were designed and synthesized. All the new derivatives were tested by p110 alpha enzymatic and Rh30 cellular assays. Further enzyme selectivity profiling proved that 6e and 7 were potential selective P13K inhibitors. (C) 2014 Ling-Hua Meng and Wen-Hu Duan. Published by Elsevier B.V. on behalf of Chinese Chemical Society and Institute of Materia Medica, Chinese Academy of Medical Sciences. All rights reserved. |
| 资助项目 | [National Natural Science Foundation of China] ; [Chinese National Science & Technology Major Project "Key New Drug Creation and Manufacturing Program"] ; [Chinese National Programs for High Technology Research and Development] ; [Shanghai Science and Technology Commission] |
| 语种 | 英语 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/285038]  |
| 专题 | 中国科学院上海药物研究所 |
| 作者单位 | 1.华东理工大学 2.中国科学院 3.中国科学院上海药物研究所 |
| 推荐引用方式 GB/T 7714 | Gao Guorui,Liu Jiali,Mei Desheng,et al. designsynthesisandbiologicalevaluationofacylhydrazonederivativesaspi3kinhibitors[J]. chinesechemicalletters,2015,26(1):118. |
| APA | Gao Guorui,Liu Jiali,Mei Desheng,Ding Jian,Meng Linghua,&Duan Wenhu.(2015).designsynthesisandbiologicalevaluationofacylhydrazonederivativesaspi3kinhibitors.chinesechemicalletters,26(1),118. |
| MLA | Gao Guorui,et al."designsynthesisandbiologicalevaluationofacylhydrazonederivativesaspi3kinhibitors".chinesechemicalletters 26.1(2015):118. |
入库方式： OAI收割
来源：上海药物研究所
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