Discovery of a novel inhibitor of NAD(P)~+-dependent malic enzyme (ME2) by high-throughput screening
文献类型：期刊论文
| 作者 | Wen Yi1; Xu Lei2; Chen Fanglei2; Gao Jing1; Li Jingya2 ; Hu Lihong2; Li Jia2
|
| 刊名 | Acta Pharmacologica Sinica
 |
| 出版日期 | 2014 |
| 卷号 | 35期号:5页码:674 |
| 关键词 | THERMAL SHIFT ASSAYS STATISTICAL PARAMETER QUALITY-CONTROL DRUG DISCOVERY RNAI SCREENS PROGRESSION MECHANISM HIT ATP malic enzyme ME2 inhibitor natural product NPD389 high-throughput screening structure-activity relationship enzyme kinetics thermal shift assay |
| ISSN号 | 1671-4083 |
| DOI | 10.1038/aps.2013.189 |
| 英文摘要 | Aim: Malic enzymes are oxidative decarboxylases with NAD(+) or NAD(P)(+) as cofactor that catalyze the conversion of L-malate to pyruvate and CO2. The aim of this study was to discover and characterize a potent inhibitor of human NAD(P)(+)-dependent malic enzyme 2 (ME2). |
| 资助项目 | [National Natural Science Foundation of China] ; [National Science and Technology Major Projects for Major New Drugs Innovation and Development] ; [Shanghai Commission of Science and Technology] |
| 语种 | 英语 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/285055]  |
| 专题 | 中国科学院上海药物研究所 |
| 作者单位 | 1.江苏大学 2.中国科学院上海药物研究所 |
| 推荐引用方式 GB/T 7714 | Wen Yi,Xu Lei,Chen Fanglei,et al. Discovery of a novel inhibitor of NAD(P)~+-dependent malic enzyme (ME2) by high-throughput screening[J]. Acta Pharmacologica Sinica,2014,35(5):674. |
| APA | Wen Yi.,Xu Lei.,Chen Fanglei.,Gao Jing.,Li Jingya.,...&Li Jia.(2014).Discovery of a novel inhibitor of NAD(P)~+-dependent malic enzyme (ME2) by high-throughput screening.Acta Pharmacologica Sinica,35(5),674. |
| MLA | Wen Yi,et al."Discovery of a novel inhibitor of NAD(P)~+-dependent malic enzyme (ME2) by high-throughput screening".Acta Pharmacologica Sinica 35.5(2014):674. |
入库方式： OAI收割
来源：上海药物研究所
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