identificationandkineticsstudyonthetransformationofmevinolininacidicalcoholsolutionbyhighperformanceliquidchromatographywithphotodiodearraydetectorormassspectrometry
文献类型：期刊论文
| 作者 | Li Yongguo1; Liu Hong2 ; Zhagn fang1; Wang Zhengtao1; Hu Zhibi1
|
| 刊名 | chemicalresearchinchineseuniversities
 |
| 出版日期 | 2006 |
| 卷号 | 22期号:4页码:500 |
| 关键词 | RED YEAST RICE BIOSYNTHESIS identification kinetic study solvates mevinolin LC-PDA-ESI-MS |
| ISSN号 | 1005-9040 |
| 英文摘要 | Mevinolin is one of the earlier statin drugs which is effective for the treatment of hypercholesterolemia, as an inhibitor of the HMG-CoA reductase. The transformations of mevinolin in acidic alcohol(such as ethanol, methanol and isopropanol) solutions caused by solvent effects were revealed in the present article. The solvates, that is, mevinolinic methyl ester, mevinolinic ethyl ester and mevinolinic isopropyl ester, were identified by LC/PDA and LC/MS. The kinetics parameters of the transformations caused by solvent effects, such as the observed rate constant of mevinolin (k(obs)) the maximum concentration ( c(max)) and its corresponding maximum time ( t(max), time for the acid form to reach the maximum concentration) of mevinolinic acid, are discussed. The influencing factors, such as the kind of Solvents, the acidic concentration, the initial mevinolin concentration, and the water content as well as temperature were investigated. Two kinds of comparative-reactions, hydrolysis and alcoholysis, of mevinolin in solution were studied. This detailed study on the kinetics of mevinolin transformations is valuable and meaningful for the purification, preparation, injection manufacturing, extraction, storage, etc., of mevinolin or other similar compounds. This work provides useful information for the quality control of mevinolin and mevinolin-like drugs as well. |
| 语种 | 英语 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/285158]  |
| 专题 | 中国科学院上海药物研究所 |
| 作者单位 | 1.上海中医药大学 2.中国科学院上海药物研究所 |
| 推荐引用方式 GB/T 7714 | Li Yongguo,Liu Hong,Zhagn fang,et al. identificationandkineticsstudyonthetransformationofmevinolininacidicalcoholsolutionbyhighperformanceliquidchromatographywithphotodiodearraydetectorormassspectrometry[J]. chemicalresearchinchineseuniversities,2006,22(4):500. |
| APA | Li Yongguo,Liu Hong,Zhagn fang,Wang Zhengtao,&Hu Zhibi.(2006).identificationandkineticsstudyonthetransformationofmevinolininacidicalcoholsolutionbyhighperformanceliquidchromatographywithphotodiodearraydetectorormassspectrometry.chemicalresearchinchineseuniversities,22(4),500. |
| MLA | Li Yongguo,et al."identificationandkineticsstudyonthetransformationofmevinolininacidicalcoholsolutionbyhighperformanceliquidchromatographywithphotodiodearraydetectorormassspectrometry".chemicalresearchinchineseuniversities 22.4(2006):500. |
入库方式： OAI收割
来源：上海药物研究所
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