pharmacologicalinhibitionofdiacylglycerolacyltransferase1reducesbodyweightgainhyperlipidemiaandhepaticsteatosisindbdbmice
文献类型：期刊论文
| 作者 | Zhang Xiaodong1; Yan Jianwei1; Yan Guirui1; Sun Xiaoyun1; Ji Jun1; Li Yiming2; Hu Youhong1 ; Wang Heyao1
|
| 刊名 | actapharmacologicasinica
 |
| 出版日期 | 2010 |
| 卷号 | 31期号:11页码:1470 |
| 关键词 | FATTY-ACID OXIDATION ACTIVATED PROTEIN-KINASE TRIGLYCERIDE SYNTHESIS METABOLIC SYNDROME INSULIN-RESISTANCE ENERGY-UTILIZATION GENE-EXPRESSION LIVER-DISEASE DGAT ENZYMES OBESITY |
| ISSN号 | 1671-4083 |
| 英文摘要 | Aim: To test whether pharmacological inhibition of Diacylglycerol acyltransferase 1 (DGAT1) by a small-molecule inhibitor H128 can improve metabolism disorders in leptin receptor-deficient db/db mice. Methods: To investigate the effect of H128 on intestinal fat absorption, db/db mice were acutely given a bolus of corn oil by gavage.The mice were further orally administered H128 (3 and 10 mg/kg) for 5 weeks. Blood glucose, lipids, insulin, ALT, and AST as well as hepatic triglycerides were measured. The insulin tolerance test was performed to evaluate insulin sensitivity. The expression of genes involved in fatty acid oxidation was detected by RT-PCR.Results: Oral administration of H128 (10 mg/kg) acutely inhibited intestinal fat absorption following a lipid challenge in db/db mice. Chronic treatment with H128 significantly inhibited body weight gain, decreased food intake, and induced a pronounced reduction ofserum triglycerides. In addition, H128 treatment markedly ameliorated hepatic steatosis, characterized by decreased liver weight, lipid droplets, and triglyceride content as well as serum ALT and AST levels. Furthermore, H128 treatment increased the expression of the CPT1 and PPARc genes in liver, suggesting that H128 enhanced fatty acid oxidation in db/db mice. However, neither blood glucose nor insulin tolerance was affected by H128 treatment throughout the 5-week experimental period. Conclusion: DGAT1 may be an effective therapeutic target for the treatment of obesity, hyperlipidemia and hepatic steatosis |
| 语种 | 英语 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/285161]  |
| 专题 | 中国科学院上海药物研究所 |
| 作者单位 | 1.中国科学院上海药物研究所 2.上海中医药大学 |
| 推荐引用方式 GB/T 7714 | Zhang Xiaodong,Yan Jianwei,Yan Guirui,et al. pharmacologicalinhibitionofdiacylglycerolacyltransferase1reducesbodyweightgainhyperlipidemiaandhepaticsteatosisindbdbmice[J]. actapharmacologicasinica,2010,31(11):1470. |
| APA | Zhang Xiaodong.,Yan Jianwei.,Yan Guirui.,Sun Xiaoyun.,Ji Jun.,...&Wang Heyao.(2010).pharmacologicalinhibitionofdiacylglycerolacyltransferase1reducesbodyweightgainhyperlipidemiaandhepaticsteatosisindbdbmice.actapharmacologicasinica,31(11),1470. |
| MLA | Zhang Xiaodong,et al."pharmacologicalinhibitionofdiacylglycerolacyltransferase1reducesbodyweightgainhyperlipidemiaandhepaticsteatosisindbdbmice".actapharmacologicasinica 31.11(2010):1470. |
入库方式： OAI收割
来源：上海药物研究所
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