treatingbreastcancermetastasiswithcabazitaxelloadedpolymericmicelles
文献类型：期刊论文
| 作者 | Zhong Tao1; He Bin2; Cao Haiqiang2; Tan Tao2; Hu Haiyan2; Li Yaping2 ; Zhang Zhiwen2
|
| 刊名 | actapharmacologicasinica
 |
| 出版日期 | 2017 |
| 卷号 | 38期号:6页码:924 |
| 关键词 | micelles cabazitaxel cancer metastasis breast cancer 4T1 breast cancer cells |
| ISSN号 | 1671-4083 |
| DOI | 10.1038/aps.2017.36 |
| 英文摘要 | Cancer metastasis is the primary cause of high mortality in breast cancer patients. In this study, we loaded an anti-cancer drug, cabazitaxel (CTX), into polymeric micelles (CTX-loaded polymeric micelles, PCMs), and explored their therapeutic efficacy in breast cancer metastasis. The characteristics of PCMs were investigated, and their anti-metastatic efficacy was assessed using in vitro and in vivo evaluations. PCMs had an average diameter of 50.13±11.96 nm with a CTX encapsulation efficiency of 97.02%±0.97%. PCMs could be effectively internalized into metastatic 4T1 breast cancer cells in vitro. CTX (10 ng/mL) or an equivalent concentration in PCMs did not significantly affected the viability of 4T1 cells, but dramatically decreased the cell migration activities. In an orthotopic metastatic breast cancer model, intravenously administered PCMs could be efficiently delivered to the tumor sites, resulting in a 71.6% inhibition of tumor growth and a 93.5% reduction of lung metastases. Taken together, our results verify the anti-metastatic efficacy of PCMs, thus providing an encouraging strategy for treating breast cancer metastasis. |
| 语种 | 英语 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/285168]  |
| 专题 | 中国科学院上海药物研究所 |
| 作者单位 | 1.南昌大学 2.中国科学院上海药物研究所 |
| 推荐引用方式 GB/T 7714 | Zhong Tao,He Bin,Cao Haiqiang,et al. treatingbreastcancermetastasiswithcabazitaxelloadedpolymericmicelles[J]. actapharmacologicasinica,2017,38(6):924. |
| APA | Zhong Tao.,He Bin.,Cao Haiqiang.,Tan Tao.,Hu Haiyan.,...&Zhang Zhiwen.(2017).treatingbreastcancermetastasiswithcabazitaxelloadedpolymericmicelles.actapharmacologicasinica,38(6),924. |
| MLA | Zhong Tao,et al."treatingbreastcancermetastasiswithcabazitaxelloadedpolymericmicelles".actapharmacologicasinica 38.6(2017):924. |
入库方式： OAI收割
来源：上海药物研究所
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