anoveltumortargetingtreatmentstrategyusesenergyrestrictionviacodeliveryofalbendazoleandnanosilver
文献类型：期刊论文
| 作者 | Liang Jianming1; Li Ruixiang1; He Yuwei1; Ling Chengli2; Wang Qi3; Huang Yongzhuo4 ; Qin Jing1; Lu Weigen5; Wang Jianxin1
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| 刊名 | nanoresearch
 |
| 出版日期 | 2018 |
| 卷号 | 011期号:009页码:4507 |
| 关键词 | 纳米技术 纳米材料 材料分析 |
| ISSN号 | 1998-0124 |
| 英文摘要 | Although nanotechnology has been rapidly developed and applied in tumor targeting, the outcome of chemotherapy remains greatly restricted by the toxicity of cytotoxic drugs in normal tissues and cells. Therefore, the development of alternative delivery systems, with few side effects in normal cells, has attracted increasing attention. Energy restriction is a novel and promising approach to cancer treatment, which can restrict tumor growth via inhibition of cellular energy metabolism. In this study, a novel tumor targeting system, based on folate-conjugated bovine serum albumin （BSA）, was developed to co-deliver albendazole and nanosilver simultaneously, to restrain the energy metabolism of tumor cells. This nanosystem showed stronger anti-tumor efficacy than those using nanoparticles without folic acid modification, nanosilver, or albendazole, both in vitro and in vivo. This nanosystem depleted cellular ATP via direct inhibition of glycolytic enzymes and mitochondrial damage, resulting in inhibition of proliferation, cell-cycle arrest, and apoptosis of tumor cells. The enhanced anti-tumor activity contributed to the tumor-targeting ability of this system, resulting in specific energy inhibition in tumor cells. Toxicity evaluation was performed to confirm the safety of this system. This nanosystem provides an efficient and safe strate~ for tumor therapy. |
| 语种 | 英语 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/285204]  |
| 专题 | 中国科学院上海药物研究所 |
| 作者单位 | 1.复旦大学 2.成都中医药大学 3.广州大学 4.中国科学院上海药物研究所 5.Shanghai Institute of Pharmaceutical Industry, China State Institute of Pharmaceutical Industry |
| 推荐引用方式 GB/T 7714 | Liang Jianming,Li Ruixiang,He Yuwei,et al. anoveltumortargetingtreatmentstrategyusesenergyrestrictionviacodeliveryofalbendazoleandnanosilver[J]. nanoresearch,2018,011(009):4507. |
| APA | Liang Jianming.,Li Ruixiang.,He Yuwei.,Ling Chengli.,Wang Qi.,...&Wang Jianxin.(2018).anoveltumortargetingtreatmentstrategyusesenergyrestrictionviacodeliveryofalbendazoleandnanosilver.nanoresearch,011(009),4507. |
| MLA | Liang Jianming,et al."anoveltumortargetingtreatmentstrategyusesenergyrestrictionviacodeliveryofalbendazoleandnanosilver".nanoresearch 011.009(2018):4507. |
入库方式： OAI收割
来源：上海药物研究所
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