tolllikereceptorspotentialtargetsforlupustreatment
文献类型：期刊论文
| 作者 | Wu Yanwei; Tang Wei ; Zuo Jianping
|
| 刊名 | actapharmacologicasinica
 |
| 出版日期 | 2015 |
| 卷号 | 36期号:12页码:1395 |
| 关键词 | PATTERN-RECOGNITION RECEPTORS ALPHA MONOCLONAL-ANTIBODY AUTOREACTIVE B-CELLS I INTERFERON DENDRITIC CELLS AUTOANTIBODY PRODUCTION RHEUMATOID-ARTHRITIS PHASE-I KINASE-ACTIVITY MESSENGER-RNAS systemic lupus erythematosus autoimmune diseases Toll-like receptors TLR antagonists immune modulatory oligonucleotides small molecular inhibitors antibodies miRNAs |
| ISSN号 | 1671-4083 |
| DOI | 10.1038/aps.2015.91 |
| 英文摘要 | Systemic lupus erythematosus (SLE) is a complex autoimmune disease characterized by the loss of tolerance to self-nuclear antigens. Accumulating evidence shows that Toll-like receptors (TLRs), previously proven to be critical for host defense, are implicated in the pathogenesis of autoimmune diseases by recognition of self-molecules. Genome-wide association studies, experimental mouse models and clinical sample studies have provided evidence for the involvement of TLRs, including TLR2/4, TLR5, TLR3 and TLR7/8/9, in SLE pathogenesis. A number of downstream proteins in the TLR signaling cascade (such as MyD88, IRAKs and IFN-alpha) are identified as potential therapeutic targets for SLE treatment. Numerous antagonists targeting TLR signaling, including oligonucleotides, small molecular inhibitors and antibodies, are currently under preclinical studies or clinical trials for SLE treatment. Moreover, the emerging new manipulation of TLR signaling by microRNA (miRNA) regulation shows promise for the future treatment of SLE. |
| 资助项目 | [National Natural Science Foundation of China] ; [National Key Basic Research Program (973 Program)] |
| 语种 | 英语 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/285344]  |
| 专题 | 中国科学院上海药物研究所 |
| 作者单位 | 中国科学院上海药物研究所 |
| 推荐引用方式 GB/T 7714 | Wu Yanwei,Tang Wei,Zuo Jianping. tolllikereceptorspotentialtargetsforlupustreatment[J]. actapharmacologicasinica,2015,36(12):1395. |
| APA | Wu Yanwei,Tang Wei,&Zuo Jianping.(2015).tolllikereceptorspotentialtargetsforlupustreatment.actapharmacologicasinica,36(12),1395. |
| MLA | Wu Yanwei,et al."tolllikereceptorspotentialtargetsforlupustreatment".actapharmacologicasinica 36.12(2015):1395. |
入库方式： OAI收割
来源：上海药物研究所
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