preclinicalpharmacokineticsoftpn729maanovelpde5inhibitorandpredictionofitshumanpharmacokineticsusingapbpkmodel
文献类型：期刊论文
| 作者 | Gao Zhiwei1; Zhu Yunting2; Yu Mingming2; Zan Bin2; Liu Jia2 ; Zhang Yifan2; Chen Xiaoyan2; Li Xuening1; Zhong Dafang2
|
| 刊名 | actapharmacologicasinica
 |
| 出版日期 | 2015 |
| 卷号 | 36期号:12页码:1528 |
| 关键词 | HUMAN DRUG CLEARANCE PHOSPHODIESTERASE-5 INHIBITORS CLINICAL PHARMACOKINETICS ERECTILE DYSFUNCTION TISSUE DISTRIBUTION ORAL PHARMACOKINETICS RECEPTOR ANTAGONIST DIVERSE COMPOUNDS IN-VIVO ABSORPTION TPN729MA PDE5 inhibitor erectile dysfunction pharmacokinetics human PK prediction physiologically based pharmacokinetic model |
| ISSN号 | 1671-4083 |
| DOI | 10.1038/aps.2015.118 |
| 英文摘要 | Aim: TPN729MA is a novel selective PDE5 inhibitor currently under clinical development in China for the treatment of erectile dysfunction. In this study we characterized its preclinical pharmacokinetics (PK) and predict its human PK using a physiologically based pharmacokinetic (PBPK) model. |
| 语种 | 英语 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/285410]  |
| 专题 | 中国科学院上海药物研究所 |
| 作者单位 | 1.复旦大学 2.中国科学院上海药物研究所 |
| 推荐引用方式 GB/T 7714 | Gao Zhiwei,Zhu Yunting,Yu Mingming,et al. preclinicalpharmacokineticsoftpn729maanovelpde5inhibitorandpredictionofitshumanpharmacokineticsusingapbpkmodel[J]. actapharmacologicasinica,2015,36(12):1528. |
| APA | Gao Zhiwei.,Zhu Yunting.,Yu Mingming.,Zan Bin.,Liu Jia.,...&Zhong Dafang.(2015).preclinicalpharmacokineticsoftpn729maanovelpde5inhibitorandpredictionofitshumanpharmacokineticsusingapbpkmodel.actapharmacologicasinica,36(12),1528. |
| MLA | Gao Zhiwei,et al."preclinicalpharmacokineticsoftpn729maanovelpde5inhibitorandpredictionofitshumanpharmacokineticsusingapbpkmodel".actapharmacologicasinica 36.12(2015):1528. |
入库方式： OAI收割
来源：上海药物研究所
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