hyperpolarizationactivatedcyclicnucleotidegatedhcnchannelsintheregulationofmidbraindopaminesystems
文献类型：期刊论文
| 作者 | Chu Hongyuan; Zhen Xuechu |
| 刊名 | actapharmacologicasinica
 |
| 出版日期 | 2010 |
| 卷号 | 31期号:9页码:1036 |
| 关键词 | VENTRAL TEGMENTAL AREA CURRENT I-H NIGRA ZONA COMPACTA PROTEIN-KINASE-C HIPPOCAMPAL PYRAMIDAL NEURONS CATION CURRENT PARKINSONS-DISEASE PACEMAKER CHANNELS WORKING-MEMORY PARS-COMPACTA dopamine drug addiction hyperpolarization-activated nucleotide-gated channels (HCN channels) midbrain Parkinson's disease |
| ISSN号 | 1671-4083 |
| DOI | 10.1038/aps.2010.105 |
| 英文摘要 | Hyperpolarization-activated, cyclic nucleotide-gated channels (HCN channels) are expressed widely in the brain and invovled in various neuronal activities, including the control of neuronal rhythmic activity, setting the resting membrane potential, as well as dendritic integration. HCN channels also participate in the regulation of spontaneous activity of midbrain dopamine (DA) neurons to some extent. In slice preparations of midbrain, a hyperpolarization-activated non-selective cation current (Ih) mediated by the channels has been proposed as an electrophysiological marker to identify DA neurons. Recent evidence, however, shows that the functional roles of HCN channels in midbrain DA neurons are obviously underestimated. Here, we review the recent advances in the studies of the functional roles of Ih in midbrain DA neurons and further, their involvement in drug addiction and Parkinson's disease. |
| 资助项目 | [National Natural Science Foundation of China] ; [Ministry of Science and Technology of China] |
| 语种 | 英语 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/285451]  |
| 专题 | 中国科学院上海药物研究所 |
| 作者单位 | 中国科学院上海药物研究所 |
| 推荐引用方式 GB/T 7714 | Chu Hongyuan,Zhen Xuechu. hyperpolarizationactivatedcyclicnucleotidegatedhcnchannelsintheregulationofmidbraindopaminesystems[J]. actapharmacologicasinica,2010,31(9):1036. |
| APA | Chu Hongyuan,&Zhen Xuechu.(2010).hyperpolarizationactivatedcyclicnucleotidegatedhcnchannelsintheregulationofmidbraindopaminesystems.actapharmacologicasinica,31(9),1036. |
| MLA | Chu Hongyuan,et al."hyperpolarizationactivatedcyclicnucleotidegatedhcnchannelsintheregulationofmidbraindopaminesystems".actapharmacologicasinica 31.9(2010):1036. |
入库方式： OAI收割
来源：上海药物研究所
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