Cholinergic deficiency involved in vascular dementia:possible mechanism and strategy of treatment
文献类型：期刊论文
| 作者 | Juan WANG; Haiyan ZHANG ; Xican TANG
|
| 刊名 | Acta Pharmacologica Sinica
 |
| 出版日期 | 2009 |
| 卷号 | 30期号:7页码:879 |
| 关键词 | NICOTINIC ACETYLCHOLINE-RECEPTORS SPONTANEOUSLY HYPERTENSIVE-RATS CHRONIC CEREBRAL HYPOPERFUSION ATTENUATES COGNITIVE DEFICITS L-ALPHA-GLYCERYLPHOSPHORYLCHOLINE ALZHEIMERS-DISEASE PATIENTS OXYGEN-GLUCOSE DEPRIVATION TRANSIENT GLOBAL-ISCHEMIA HUPERZINE-A DOUBLE-BLIND vascular dementia cholinergic deficit acetylcholinesterase inhibitor inflammation |
| ISSN号 | 1671-4083 |
| DOI | 10.1038/aps.2009.82 |
| 英文摘要 | Vascular dementia (VaD) is a progressive neurodegenerative disease with a high prevalence. Several studies have recently reported that VaD patients present cholinergic deficits in the brain and cerebrospinal fluid (CSF) that may be closely related to the pathophysiology of cognitive impairment. Moreover, cholinergic therapies have shown promising effects on cognitive improvement in VaD patients. The precise mechanisms of these cholinergic agents are currently not fully understood; however, accumulating evidence indicates that these drugs may act through the cholinergic anti-inflammatory pathway, in which the efferent vagus nerve signals suppress pro-inflammatory cytokine release and inhibit inflammation, although regulation of oxidative stress and energy metabolism, alleviation of apoptosis may also be involved. In this paper, we provide a brief overview of the cholinergic treatment strategy for VaD and its relevant mechanisms of anti-inflammation. |
| 资助项目 | [Ministry of Science and Technology of China] ; [National Natural Science Foundation of China] ; [Knowledge Innovation Program of the Chinese Academy of Sciences] |
| 语种 | 英语 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/285608]  |
| 专题 | 中国科学院上海药物研究所 |
| 作者单位 | 中国科学院上海药物研究所 |
| 推荐引用方式 GB/T 7714 | Juan WANG,Haiyan ZHANG,Xican TANG. Cholinergic deficiency involved in vascular dementia:possible mechanism and strategy of treatment[J]. Acta Pharmacologica Sinica,2009,30(7):879. |
| APA | Juan WANG,Haiyan ZHANG,&Xican TANG.(2009).Cholinergic deficiency involved in vascular dementia:possible mechanism and strategy of treatment.Acta Pharmacologica Sinica,30(7),879. |
| MLA | Juan WANG,et al."Cholinergic deficiency involved in vascular dementia:possible mechanism and strategy of treatment".Acta Pharmacologica Sinica 30.7(2009):879. |
入库方式： OAI收割
来源：上海药物研究所
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