hypoxiainducesuniversalbutdifferentialdrugresistanceandimpairsanticancermechanismsof5fluorouracilinhepatomacells
文献类型：期刊论文
| 作者 | Li Jingqiu1; Wu Xian1; Gan Lu1; Yang Xiangliang1; Mlao Zehong2 |
| 刊名 | actapharmacologicasinica
 |
| 出版日期 | 2017 |
| 卷号 | 38期号:12页码:1642 |
| 关键词 | hepatocellular carcinoma hypoxia 5-fluorouracil sorafenib drug resistance |
| ISSN号 | 1671-4083 |
| DOI | 10.1038/aps.2017.79 |
| 英文摘要 | Hepatocellular carcinoma (HCC) is one of the most refractory cancers. The mechanisms by which hypoxia further aggravates therapeutic responses of advanced HCC to anticancer drugs remain to be clarified. Here, we report that hypoxia (1% O_2) caused 2.55-489.7-fold resistance to 6 anticancer drugs (sorafenib, 5-fluorouracil 5-FU |
| 语种 | 英语 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/285728]  |
| 专题 | 中国科学院上海药物研究所 |
| 作者单位 | 1.华中科技大学 2.中国科学院上海药物研究所 |
| 推荐引用方式 GB/T 7714 | Li Jingqiu,Wu Xian,Gan Lu,et al. hypoxiainducesuniversalbutdifferentialdrugresistanceandimpairsanticancermechanismsof5fluorouracilinhepatomacells[J]. actapharmacologicasinica,2017,38(12):1642. |
| APA | Li Jingqiu,Wu Xian,Gan Lu,Yang Xiangliang,&Mlao Zehong.(2017).hypoxiainducesuniversalbutdifferentialdrugresistanceandimpairsanticancermechanismsof5fluorouracilinhepatomacells.actapharmacologicasinica,38(12),1642. |
| MLA | Li Jingqiu,et al."hypoxiainducesuniversalbutdifferentialdrugresistanceandimpairsanticancermechanismsof5fluorouracilinhepatomacells".actapharmacologicasinica 38.12(2017):1642. |
入库方式： OAI收割
来源：上海药物研究所
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