tatfunctionalizedagfe3o4nanocompositesastissuepenetratingvehiclesfortumormagnetictargetinganddrugdelivery
文献类型：期刊论文
| 作者 | Liu Ergang1; Zhang Meng2; Cui Hui3; Gong Junbo1; Huang Yongzhuo2 ; Wang Jianxin4; Cui Yanna2; Dong Weibing1; Sun Lu3; He Huining3
|
| 刊名 | actapharmaceuticasinicab
 |
| 出版日期 | 2018 |
| 卷号 | 000期号:006页码:956 |
| 关键词 | Cell penetrating peptide Tat Silver nanoparticles Magnetic targeting Fe3O4 Hydrazone bond |
| ISSN号 | 2211-3835 |
| 英文摘要 | In this paper, we prepared a dual functional system based on dextrin-coated silver nanoparticles which were further attached with iron oxide nanoparticles and cell penetrating peptide（Tat）, producing Tat-modified Ag-Fe3O4 nanocomposites（Tat-FeAgNPs）. To load drugs, an –SH containing linker, 3-mercaptopropanohydrazide, was designed and synthesized. It enabled the silver carriers to load and release doxorubicin（Dox） in a pH-sensitive pattern. The delivery efficiency of this system was assessed in vitro using MCF-7 cells, and in vivo using null BalB/c mice bearing MCF-7 xenograft tumors. Our results demonstrated that both Tat and externally applied magnetic field could promote cellular uptake and consequently the cytotoxicity of doxorubicin-loaded nanoparticles,with the IC50 of Tat-FeAgNP-Dox to be 0.63 mmol/L. The in vivo delivery efficiency of Tat-FeAgNP carrying Cy5 to the mouse tumor was analyzed using the in vivo optical imaging tests, in which TatFeAgNP-Cy5 yielded the most efficient accumulation in the tumor（6.772.4% ID of Tat-FeAgNPs）.Anti-tumor assessment also demonstrated that Tat-FeAgNP-Dox displayed the most significant tumor-inhibiting effects and reduced the specific growth rate of tumor by 29.6%（P ? 0.009）, which could be attributed to its superior performance in tumor drug delivery in comparison with the control nanovehicles. |
| 语种 | 英语 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/285776]  |
| 专题 | 中国科学院上海药物研究所 |
| 作者单位 | 1.School of Chemical Engineering and Technology,Tianjin University 2.中国科学院上海药物研究所 3.School of Pharmacy,Tianjin Medical University 4.Department of Pharmaceutics,School of Pharmacy,Fudan University |
| 推荐引用方式 GB/T 7714 | Liu Ergang,Zhang Meng,Cui Hui,et al. tatfunctionalizedagfe3o4nanocompositesastissuepenetratingvehiclesfortumormagnetictargetinganddrugdelivery[J]. actapharmaceuticasinicab,2018,000(006):956. |
| APA | Liu Ergang.,Zhang Meng.,Cui Hui.,Gong Junbo.,Huang Yongzhuo.,...&Yang Victor C.(2018).tatfunctionalizedagfe3o4nanocompositesastissuepenetratingvehiclesfortumormagnetictargetinganddrugdelivery.actapharmaceuticasinicab,000(006),956. |
| MLA | Liu Ergang,et al."tatfunctionalizedagfe3o4nanocompositesastissuepenetratingvehiclesfortumormagnetictargetinganddrugdelivery".actapharmaceuticasinicab 000.006(2018):956. |
入库方式： OAI收割
来源：上海药物研究所
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