5r5hydroxytriptolideamelioratesantiglomerularbasementmembraneglomerulonephritisinnzwmicebyregulatingfcyreceptorsignaling
文献类型：期刊论文
| 作者 | Qi Qing1; Li Heng2; Lin Zemin1; Yang Xiaoqian2; Zhu Fenghua2; Liu Yuting2; Shao Meijuan1; Zhang Luyao2; Yanshengxu1; Yan Yuxi2 |
| 刊名 | actapharmacologicasinica
 |
| 出版日期 | 2018 |
| 卷号 | 39期号:1页码:107 |
| 关键词 | triptolide (5R)-5-hydroxytriptolide (LLDT-8) prednisolone glomerulonephritis immune complexes inflammation Fcy receptor signaling |
| ISSN号 | 1671-4083 |
| DOI | 10.1038/aps.2017.88 |
| 英文摘要 | (5R)-5-hydroxytriptolide (LLDT-8) is a novel triptolide analog that has been identified as a promising candidate for treating autoimmune diseases and has been shown to be effective in treating murine collagen-induced arthritis and lupus nephritis. In the present study, we investigated the therapeutic effect and possible mechanism of action of LLDT-8 in a murine anti-glomerular basement membrane (GBM) glomerulonephritis model. NZW mice were injected with rabbit anti-GBM serum (500 μL,ip). The mice were orally treated with LLDT-8 (0.125 mg/kg, every other day) or a positive control prednisolone (2 mg/kg every day) for 14 d. Blood and urine samples as well as spleen and kidney tissues were collected for analyses. LLDT-8 treatment did not affect the generation of mouse anti-rabbit antibodies. LLDT-8 significantly reversed established proteinuria, improved renal histopathology and attenuated renal dysfunction in glomerulonephritis mice. Furthermore, LLDT-8 inhibited inflammation in the kidney evidenced by significantly decreasing C3 and IgG deposition, reducing the levels of the pathogenic cytokines TNF-a, IL-6,IL-17, and IFN-γ,and reducing related chemokine expression and leukocyte infiltration in kidneys. Moreover, LLDT-8 treatment significantly increased the expression of FcγRIIB in the kidney and spleen. In addition, the treatment restored the reduced expression of FcγRIIB on the surface of kidney effector cells,CD11b~+ cells, and interfered with FcyR-dependent signaling, especially FcyRIIB-mediated downstream kinases, such as BTK. These results demonstrate that LLDT-8 ameliorates anti-GBM glomerulonephritis by regulating the Fcy receptor signaling. |
| 语种 | 英语 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/285785]  |
| 专题 | 中国科学院上海药物研究所 |
| 作者单位 | 1.上海中医药大学 2.中国科学院上海药物研究所 |
| 推荐引用方式 GB/T 7714 | Qi Qing,Li Heng,Lin Zemin,et al. 5r5hydroxytriptolideamelioratesantiglomerularbasementmembraneglomerulonephritisinnzwmicebyregulatingfcyreceptorsignaling[J]. actapharmacologicasinica,2018,39(1):107. |
| APA | Qi Qing.,Li Heng.,Lin Zemin.,Yang Xiaoqian.,Zhu Fenghua.,...&Jianpingzuo.(2018).5r5hydroxytriptolideamelioratesantiglomerularbasementmembraneglomerulonephritisinnzwmicebyregulatingfcyreceptorsignaling.actapharmacologicasinica,39(1),107. |
| MLA | Qi Qing,et al."5r5hydroxytriptolideamelioratesantiglomerularbasementmembraneglomerulonephritisinnzwmicebyregulatingfcyreceptorsignaling".actapharmacologicasinica 39.1(2018):107. |
入库方式： OAI收割
来源：上海药物研究所
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