threenewalkaloidsisolatedfromthestemtuberofpinelliapedatisecta
文献类型：期刊论文
| 作者 | Du Jing2; Ding Jie2; Mu Zhenqiang2; Guan Shuhong1 ; Cheng Chunru2; Liu Xuan3; Guo Dean1
|
| 刊名 | chinesejournalofnaturalmedicines
 |
| 出版日期 | 2018 |
| 卷号 | 016期号:002页码:139 |
| 关键词 | 孤立 茎 碱 化学成分 光谱数据 物理化学 混合物 醋酸盐 |
| ISSN号 | 2095-6975 |
| 英文摘要 | The present study was designed to determine the chemical constituents of the stem tuber of Pinellia pedatisecta. The chemical constituents were isolated and purified by various chromatographic techniques, and their structures were elucidated on the basis of physicochemical properties and spectral data. Three new alkaloids（compounds 1, 2, and 3） were obtained and identified as 9-（（5-methoxypyridin-2-yl）methyl）-9 H-purin-6-amine（1）, 4-（2-（2, 5-dioxopyrrolidin-1-yl）ethyl）phenyl acetate（2）, and N-（9-（（5-methoxypyridin-2-yl）methyl）-9 H-purin-6-yl）acetamide（3）. These compounds were evaluated for their cytotoxicity against human cervical cancer He La cells. Compounds 1 and 3 significantly inhibited the proliferation of He La cells with IC_（50） values being 3.02 ± 0.54 and 7.16 ± 0.62 μmol·L~（-1）, respectively. |
| 语种 | 英语 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/285883]  |
| 专题 | 中国科学院上海药物研究所 |
| 作者单位 | 1.中国科学院上海药物研究所 2.四川大学 3.上海中医药大学 |
| 推荐引用方式 GB/T 7714 | Du Jing,Ding Jie,Mu Zhenqiang,et al. threenewalkaloidsisolatedfromthestemtuberofpinelliapedatisecta[J]. chinesejournalofnaturalmedicines,2018,016(002):139. |
| APA | Du Jing.,Ding Jie.,Mu Zhenqiang.,Guan Shuhong.,Cheng Chunru.,...&Guo Dean.(2018).threenewalkaloidsisolatedfromthestemtuberofpinelliapedatisecta.chinesejournalofnaturalmedicines,016(002),139. |
| MLA | Du Jing,et al."threenewalkaloidsisolatedfromthestemtuberofpinelliapedatisecta".chinesejournalofnaturalmedicines 016.002(2018):139. |
入库方式： OAI收割
来源：上海药物研究所
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