structuralstudiesonanunusualnovelmacrocyclicpolydisulfidefromthechinesemangrovebruguieragymnorrhiza
文献类型：期刊论文
| 作者 | Liu HL(刘海利); Shen X(沈旭) ; Jiang HL(蒋华良); Guo YW(郭跃伟)
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| 刊名 | chinesejournaloforganicchemistry
 |
| 出版日期 | 2008 |
| 卷号 | 28期号:2页码:246 |
| 关键词 | EXCOECARIA-AGALLOCHA-L CRYSTAL-STRUCTURE DISULFIDES 1,2-DITHIOLANE SPORIDESMINS DITERPENES ALKALOIDS SEXANGULA Bruguiera gymnorrhiza macrocyclic polydisulfide neogymnorrhizol gymnorrhizol hPTP1B inhibitory activity |
| ISSN号 | 0253-2786 |
| 英文摘要 | Chemical study on the mangrove Bruguiera gymnorrhiza collected from Zhanjiang has resulted in the isolation of an unusual novel macrocyclic polydisulfide, neogymnorrhizol (1), which possesses an unprecedented carbon skeleton characterized by a twenty-membered macrocycle that is composed of four repeated 1,3-dimercaptopropan-2-ol units, along with four known related compounds. The structure of the new compound 1 was determined by detailed spectroscopic data analysis (IR, H-1 NMR, C-13 NMR, 2D NMR, MS, etc.). The known compounds, namely gymnorrhizol (2a), bruguiesulfurol (3), brugierol (4) and isobrugierol (5), were determined by either an X-ray diffraction analysis or comparison with the data reported in the literatures. A plausible biogenetic origin of these uncommon polydisulfides and their biogenetic relationship were also discussed. In bioassay, compounds 2a and 3 exhibited significant hPTP1B inhibitory activity. |
| 语种 | 英语 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/285993]  |
| 专题 | 中国科学院上海药物研究所 |
| 作者单位 | 中国科学院上海药物研究所 |
| 推荐引用方式 GB/T 7714 | Liu HL,Shen X,Jiang HL,et al. structuralstudiesonanunusualnovelmacrocyclicpolydisulfidefromthechinesemangrovebruguieragymnorrhiza[J]. chinesejournaloforganicchemistry,2008,28(2):246. |
| APA | 刘海利,沈旭,蒋华良,&郭跃伟.(2008).structuralstudiesonanunusualnovelmacrocyclicpolydisulfidefromthechinesemangrovebruguieragymnorrhiza.chinesejournaloforganicchemistry,28(2),246. |
| MLA | 刘海利,et al."structuralstudiesonanunusualnovelmacrocyclicpolydisulfidefromthechinesemangrovebruguieragymnorrhiza".chinesejournaloforganicchemistry 28.2(2008):246. |
入库方式： OAI收割
来源：上海药物研究所
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