therapeuticeffectsoftheartemisininanalogsm934onlupuspronemrllprmiceviainhibitionoftlrtriggeredbcellactivationandplasmacellformation
文献类型：期刊论文
| 作者 | Wu Yanwei2; He Shijun2 ; Bai Bingxin1; Zhang Luyao2; Xue Lu1; Lin Zemin1; Yang Xiaoqian2; Zhu Fenghua2; He Peilan2; Tang Wei2
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| 刊名 | cellularmolecularimmunology
 |
| 出版日期 | 2016 |
| 卷号 | 13期号:3页码:379 |
| 关键词 | B cell plasma cell SM934 systemic lupus erythematosus Toll-like receptor |
| ISSN号 | 2042-0226 |
| 英文摘要 | We previously reported that SM934, a water-soluble artemisinin derivative, was a viable treatment in murine lupus models. In the current study, we further investigated the therapeutic effects of a modified dosage regimen of SM934 on lupus-prone MRL/lpr mice and explored its effects on B cell responses, a central pathogenic event in systemic lupus erythematosus (SLE). When orally administered twice-daily, SM934 significantly prolonged the life-span of MRL/lpr mice, ameliorated the lymphadenopathy symptoms and decreased the levels of serum anti-nuclear antibodies (ANAs) and of the pathogenic cytokines IL-6, IL-10 and IL-21. Furthermore, SM934 treatment restored the B-cell compartment in the spleen of MRL/lpr mice by increasing quiescent B cell numbers, maintaining germinal center B-cell numbers, decreasing activated B cell numbers and reducing plasma cell (PC) numbers. Ex vivo, SM934 suppressed the Toll-like receptor (TLR)-triggered activation and proliferation of B cells, as well as antibody secretion. Moreover, the present study demonstrated that SM934 interfered with the B-cell intrinsic pathway by downregulating TLR7/9 mRNA expression, MyD88 protein expression and NF-kB phosphorylation. In human peripheral blood mononuclear cells (PBMCs), consistent with the results in MRL/lpr mice, SM934 inhibited TLR-associated B-cell activation and PC differentiation. In conclusion, a twice daily dosing regimen of SM934 had therapeutic effects on lupus-prone MRL/lpr mice by suppressing B cell activation and plasma cell formation. |
| 语种 | 英语 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/285999]  |
| 专题 | 中国科学院上海药物研究所 |
| 作者单位 | 1.上海中医药大学 2.中国科学院上海药物研究所 |
| 推荐引用方式 GB/T 7714 | Wu Yanwei,He Shijun,Bai Bingxin,et al. therapeuticeffectsoftheartemisininanalogsm934onlupuspronemrllprmiceviainhibitionoftlrtriggeredbcellactivationandplasmacellformation[J]. cellularmolecularimmunology,2016,13(3):379. |
| APA | Wu Yanwei.,He Shijun.,Bai Bingxin.,Zhang Luyao.,Xue Lu.,...&Zuo Jianping.(2016).therapeuticeffectsoftheartemisininanalogsm934onlupuspronemrllprmiceviainhibitionoftlrtriggeredbcellactivationandplasmacellformation.cellularmolecularimmunology,13(3),379. |
| MLA | Wu Yanwei,et al."therapeuticeffectsoftheartemisininanalogsm934onlupuspronemrllprmiceviainhibitionoftlrtriggeredbcellactivationandplasmacellformation".cellularmolecularimmunology 13.3(2016):379. |
入库方式： OAI收割
来源：上海药物研究所
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