designsynthesisandevaluationofpotentgproteincoupledreceptor40agonists
文献类型：期刊论文
| 作者 | Huang Jing1; Guo Bin2 ; Chu Wenjing2; Xie Xin2; Yang Yushe2; Zhou Xianli1
|
| 刊名 | chinesechemicalletters
 |
| 出版日期 | 2016 |
| 卷号 | 27期号:1页码:159 |
| 关键词 | GPR40 Anti-diabetic Agonist Phenylpropionic acid derivative |
| ISSN号 | 1001-8417 |
| 英文摘要 | In order to find a novel GPR40 agonist with improved metabolic and safety profiles, a series of novel phenylpropanoic acid derivatives were synthesized and evaluated for their agonistic activity on GPR40. SAR study and structural modification led to identification of compounds 22g and 23e as potent GPR40 agonists with moderate liver microsomal stability. |
| 语种 | 英语 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/286016]  |
| 专题 | 中国科学院上海药物研究所 |
| 作者单位 | 1.School of Life Science and Engineering, Southwest Jiao Tong University 2.中国科学院上海药物研究所 |
| 推荐引用方式 GB/T 7714 | Huang Jing,Guo Bin,Chu Wenjing,et al. designsynthesisandevaluationofpotentgproteincoupledreceptor40agonists[J]. chinesechemicalletters,2016,27(1):159. |
| APA | Huang Jing,Guo Bin,Chu Wenjing,Xie Xin,Yang Yushe,&Zhou Xianli.(2016).designsynthesisandevaluationofpotentgproteincoupledreceptor40agonists.chinesechemicalletters,27(1),159. |
| MLA | Huang Jing,et al."designsynthesisandevaluationofpotentgproteincoupledreceptor40agonists".chinesechemicalletters 27.1(2016):159. |
入库方式： OAI收割
来源：上海药物研究所
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