5r5hydroxytriptolidelldt8protectsagainstbleomycininducedlungfibrosisinmice
文献类型：期刊论文
| 作者 | Yongxin REN; Ru ZHOU; Wei TANG ; Wenhai WANG; Yuanchao LI; Yifu YANG; Jianping ZUO
|
| 刊名 | actapharmacologicasinica
 |
| 出版日期 | 2007 |
| 卷号 | 28期号:4页码:518 |
| 关键词 | IDIOPATHIC PULMONARY-FIBROSIS WILFORDII HOOK-F COLLAGEN-INDUCED ARTHRITIS INDUCED CYTOKINE T-CELLS IN-VIVO INJURY TRIPTOLIDE GENE RATS (5R)-5-hydroxytriptolide bleomycin lung fibrosis cytokines |
| ISSN号 | 1671-4083 |
| DOI | 10.1111/j.1745-7254.2007.00524.x |
| 英文摘要 | Aim: To study the protective effects of a triptolide-derived, novel compound, (5R)-5-hydroxytriptolide (LLDT-8), on bleomycin-induced lung fibrosis. Methods: C57BL/6 mice received an intratracheal injection of bleomycin and were then treated with LLDT-8 (0.5, 1, 2 mg/kg, ip) once daily for 7 or 14 consecutive days. The body weight loss and lung index augmentation was observed; the inflammatory response including differential cells counts of neutrophils, macrophages, and lymphocytes in the bronchoalveolar lavage fluid (BALF), superoxide dismutase (SOD), and malondialdehyde (MDA) level in the lung homogenates was detected, and the fibrosis extent was evaluated by hydroxyproline content and histopathological changes in the lungs. In addition, the pro-inflammatory and pro-fibrotic cytokines, tumor necrosis factor-alpha (TNF-alpha), interleukin-4 (IL-4), and transforming growth factor-alpha (TGF-alpha) production in the lungs were measured. Results: LLDT-8 alleviated the body weight loss and lung index increase caused by bleomycin, reduced neutrophils and lymphocytes in the BALF, promoted SOD activity, decreased MDA production, and inhibited the hydroxyproline level and the amelioration of lung tissue histological damage. Moreover, LLDT-8 suppressed TNF-alpha, IL-4, an d TGF-beta production in the lun g homogenates. Conclusion: LLDT-8 sh owed protective effects against bleomycin-induced lung fibrosis, and the results suggested the potential role of LLDT-8 in the treatment of this disease. |
| 语种 | 英语 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/286082]  |
| 专题 | 中国科学院上海药物研究所 |
| 作者单位 | 中国科学院上海药物研究所 |
| 推荐引用方式 GB/T 7714 | Yongxin REN,Ru ZHOU,Wei TANG,et al. 5r5hydroxytriptolidelldt8protectsagainstbleomycininducedlungfibrosisinmice[J]. actapharmacologicasinica,2007,28(4):518. |
| APA | Yongxin REN.,Ru ZHOU.,Wei TANG.,Wenhai WANG.,Yuanchao LI.,...&Jianping ZUO.(2007).5r5hydroxytriptolidelldt8protectsagainstbleomycininducedlungfibrosisinmice.actapharmacologicasinica,28(4),518. |
| MLA | Yongxin REN,et al."5r5hydroxytriptolidelldt8protectsagainstbleomycininducedlungfibrosisinmice".actapharmacologicasinica 28.4(2007):518. |
入库方式： OAI收割
来源：上海药物研究所
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