Magnesium lithospermate B dilates mesenteric arteries by activating BK_ca currents and contracts arteries by inhibiting K_v currents
文献类型：期刊论文
| 作者 | Zhang Haifei; Chen Xueqing; Hu Guoyuan; Wang Yiping
|
| 刊名 | Acta Pharmacologica Sinica
 |
| 出版日期 | 2010 |
| 卷号 | 31期号:6页码:665 |
| 关键词 | SALVIAE-MILTIORRHIZAE-RADIX SMOOTH-MUSCLE-CELLS POTASSIUM CHANNELS ACID-B CORONARY-ARTERY RAT EXTRACTS MYOCYTES |
| ISSN号 | 1671-4083 |
| 英文摘要 | Aim: To examine the involvement of K + channels and endothelium in the vascular effects of magnesium lithospermate B (MLB), a hydrophilic active component of Salviae miltiorrhiza Radix. Methods: Isolated rat mesenteric artery rings were employed to investigate the effects of MLB on KCl- or norepinephrine-induced contractions. Conventional whole-cell patch-clamp technique was used to study the effects of MLB on K + currents in single isolated mesenteric artery myocytes. Results: MLB produced a concentration-dependent relaxation in mesenteric artery rings precontracted by norepinephrine (1 μmol 50 of 111.3 μmol 50 of 224.4 μmol N -nitro- L -arginine methyl ester ( L -NAME) with a maximal value of 130.3%. The vasodilatory effect of MLB was inhibited by tetraethylammonium (TEA) in both intact and denuded artery rings. In single smooth muscle cells, MLB activated BK Ca currents (EC 50 156.3 μmol V currents (IC 50 26.1 μmol Conclusion: MLB dilated arteries by activating BK Ca channels in smooth muscle cells and increasing NO release from endothelium, but it also contracted arteries precontracted with KCl in the presence of L -NAME. |
| 语种 | 英语 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/286251]  |
| 专题 | 中国科学院上海药物研究所 |
| 作者单位 | 中国科学院上海药物研究所 |
| 推荐引用方式 GB/T 7714 | Zhang Haifei,Chen Xueqing,Hu Guoyuan,et al. Magnesium lithospermate B dilates mesenteric arteries by activating BK_ca currents and contracts arteries by inhibiting K_v currents[J]. Acta Pharmacologica Sinica,2010,31(6):665. |
| APA | Zhang Haifei,Chen Xueqing,Hu Guoyuan,&Wang Yiping.(2010).Magnesium lithospermate B dilates mesenteric arteries by activating BK_ca currents and contracts arteries by inhibiting K_v currents.Acta Pharmacologica Sinica,31(6),665. |
| MLA | Zhang Haifei,et al."Magnesium lithospermate B dilates mesenteric arteries by activating BK_ca currents and contracts arteries by inhibiting K_v currents".Acta Pharmacologica Sinica 31.6(2010):665. |
入库方式： OAI收割
来源：上海药物研究所
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