dcz3301anovelarylguanidinoinhibitorinducescellapoptosisandcellcyclearrestviasuppressingthepi3kaktpathwayintcellleukemialymphoma
文献类型：期刊论文
| 作者 | Xiao Wenqin1; Li Bo2; Sun Xi1; Yu Dandan1; Xie Yongsheng1; Wu Huiqun1; Chang Shuaikang1; Zhou Yunfei2; Wang Houcai1; Lan Xiucai1 |
| 刊名 | actabiochimicaetbiophysicasinica
 |
| 出版日期 | 2018 |
| 卷号 | 50期号:7页码:643 |
| 关键词 | ACUTE LYMPHOBLASTIC-LEUKEMIA NON-HODGKIN-LYMPHOMA SIGNALING PATHWAYS DEATH PROTEIN LINES DCZ3301 T-cell leukemia/lymphoma apoptosis cell cycle PI3K/AKT |
| ISSN号 | 1672-9145 |
| DOI | 10.1093/abbs/gmy047 |
| 英文摘要 | DCZ3301, a novel aryl-guanidino compound, was previously found to have potent anti-tumor activity in myeloma and B-cell lymphoma. In the present study, we investigated the effects of DCZ3301 on T-cell leukemia/lymphoma cells both in vitro and in vivo via cell proliferation, cell cycle analysis, apoptosis assay, mitochondrial membrane potential (MMP) assay, western blot analysis and tumor xenograft models. We found that DCZ3301 inhibited the viability of T-cell leukemia/lymphoma cells in a dose-and time-dependent manner. DCZ3301-induced G2/M cell cycle arrest, associated with downregulation of CDK1, cyclin B1, and cdc25C. DCZ3301 also induced cell apoptosis by decreasing MMP in T-cell leukemia/lymphoma cells, but had no significant pro-apoptotic effect on normal peripheral blood mononuclear cells (PBMCs). In addition, DCZ3301-induced apoptosis may be mediated by the caspase-dependent pathway and suppressing the phosphoinositide 3-kinase (PI3K)/AKT pathway. Finally, we showed that DCZ3301 treatment effectively inhibited tumor growth, with no significant side effects, in xenograft mouse models. In conclusion, these results suggest that DCZ3301 may be regarded as a new therapeutic strategy for T-cell leukemia/lymphoma patients. |
| 资助项目 | [National Natural Science Foundation of China] |
| 语种 | 英语 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/286394]  |
| 专题 | 中国科学院上海药物研究所 |
| 作者单位 | 1.同济大学 2.中国科学院上海药物研究所 |
| 推荐引用方式 GB/T 7714 | Xiao Wenqin,Li Bo,Sun Xi,et al. dcz3301anovelarylguanidinoinhibitorinducescellapoptosisandcellcyclearrestviasuppressingthepi3kaktpathwayintcellleukemialymphoma[J]. actabiochimicaetbiophysicasinica,2018,50(7):643. |
| APA | Xiao Wenqin.,Li Bo.,Sun Xi.,Yu Dandan.,Xie Yongsheng.,...&Zhu Weiliang.(2018).dcz3301anovelarylguanidinoinhibitorinducescellapoptosisandcellcyclearrestviasuppressingthepi3kaktpathwayintcellleukemialymphoma.actabiochimicaetbiophysicasinica,50(7),643. |
| MLA | Xiao Wenqin,et al."dcz3301anovelarylguanidinoinhibitorinducescellapoptosisandcellcyclearrestviasuppressingthepi3kaktpathwayintcellleukemialymphoma".actabiochimicaetbiophysicasinica 50.7(2018):643. |
入库方式： OAI收割
来源：上海药物研究所
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