中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
effectsofdroloxifeneonapoptosisandbaxbcl2proteinexpressionoflutealcellsinpseudopregnantrats

文献类型:期刊论文

作者Feng Ying; Leng Ying; Cao Lin; Gu Zhiping
刊名actapharmacologicasinica
出版日期2001
卷号22期号:2页码:155
关键词CORPUS-LUTEUM CORPORA-LUTEA IN-VIVO DEATH LUTEOLYSIS REGRESSION FRAGMENTATION PROLIFERATION HOMOLOG WOMEN droloxifene corpus luteum rats pseudopregnancy apoptosis proteins
ISSN号0253-9756
英文摘要AIM: To study the effects of droloxifene on apoptosis and the expression of Bax and Bcl-2 protein in corpus luteum of pseudopregnant rats. METHODS: HE staining was used to examine the histological changes of ovaries. Apoptosis detection in situ was performed with TUNEL method. Expression of Bax and Bcl-2 protein was observed by immunohistochemistry analysis. RESULTS: Apoptosis of luteal cells during the spontaneous regression of corpus luteum of pseudopregnant rats appeared on d 13 of pseudopregnancy, and the marked increase of apoptotic luteal cells could be observed on d 15. When pseudopregnant rats were treated with droloxifene 20 mg.Kg(-1) on d 2, apoptosis of luteal cells could be observed on d 8, and the duration of pseudopregnancy could be shortened from (15.5 +/- 1.1) d to (12.8 +/- 1.6) d. In pseudopregnant rats, the expression of Ear and Bcl-2 protein was found in the cytoplasm of luteal cells. However, no obvious differences in the intensity or localization could be found during various days of the pseudopregnancy, while an increase in Fax and a decrease in Bcl-2 protein expression could be induced by droloxifene treatment. CONCLUSION: Droloxifene could facilitate apoptosis of luteal cells in pseudopregnant rats and shorten the period of pseudopregnancy. An increased Bax/Bcl-2 ratio might be involved in the facilitation of apoptosis induced by droloxifene in corpus luteum of pseudopregnant rats.
语种英语
源URL[http://119.78.100.183/handle/2S10ELR8/286588]  
专题中国科学院上海药物研究所
作者单位中国科学院上海药物研究所
推荐引用方式
GB/T 7714
Feng Ying,Leng Ying,Cao Lin,et al. effectsofdroloxifeneonapoptosisandbaxbcl2proteinexpressionoflutealcellsinpseudopregnantrats[J]. actapharmacologicasinica,2001,22(2):155.
APA Feng Ying,Leng Ying,Cao Lin,&Gu Zhiping.(2001).effectsofdroloxifeneonapoptosisandbaxbcl2proteinexpressionoflutealcellsinpseudopregnantrats.actapharmacologicasinica,22(2),155.
MLA Feng Ying,et al."effectsofdroloxifeneonapoptosisandbaxbcl2proteinexpressionoflutealcellsinpseudopregnantrats".actapharmacologicasinica 22.2(2001):155.

入库方式: OAI收割

来源:上海药物研究所

浏览0
下载0
收藏0
其他版本

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。