ampkregulatesanaphasecentralspindlelengthbyphosphorylationofkif4a
文献类型：期刊论文
| 作者 | Li Qianru1; Yan Xiumin2; Guo Lin3; Li Jia1 ; Zang Yi1
|
| 刊名 | journalofmolecularcellbiology
 |
| 出版日期 | 2018 |
| 卷号 | 010期号:001页码:2 |
| 关键词 | AMPK 长度 锭子 中央 后期 调整 有丝分裂 力传感器 |
| ISSN号 | 1674-2788 |
| 英文摘要 | AMP-activated protein kinase （AMPK） is an energy sensor that couples the cellular energy state with basic biological processes. AMPK is thought to be linked with cell division although the underlying mechanisms remain largely unknown. Here, we show that AMPK functionally participates throughout cell division and that AMPK catalytic subunits, especially α2, are sequentially associated with separate mitotic apparatus. Using quantitative phosphoproteomics analysis, we found that the strong direct sub- strate KIF4A is phosphorylated by AMPK at Set801. Further analysis revealed that AMPK and Aurora B competitively phosphore- gulates KIF4A during mitotic phase due to overlapping recognition motifs, resulting in the elaborate phosphoregutation for KIF4A-dependent central spindle length control. Given the intrinsic energy-sensing function of AMPK, our study links the KIF4A- dependent control of central spindle length with cellular glucose stress. |
| 语种 | 英语 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/286886]  |
| 专题 | 中国科学院上海药物研究所 |
| 作者单位 | 1.中国科学院上海药物研究所 2.中国科学院上海生命科学研究院 3.武汉大学 |
| 推荐引用方式 GB/T 7714 | Li Qianru,Yan Xiumin,Guo Lin,et al. ampkregulatesanaphasecentralspindlelengthbyphosphorylationofkif4a[J]. journalofmolecularcellbiology,2018,010(001):2. |
| APA | Li Qianru,Yan Xiumin,Guo Lin,Li Jia,&Zang Yi.(2018).ampkregulatesanaphasecentralspindlelengthbyphosphorylationofkif4a.journalofmolecularcellbiology,010(001),2. |
| MLA | Li Qianru,et al."ampkregulatesanaphasecentralspindlelengthbyphosphorylationofkif4a".journalofmolecularcellbiology 010.001(2018):2. |
入库方式： OAI收割
来源：上海药物研究所
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