dw10075anovelselectiveandsmallmoleculeinhibitorofvegfrexhibitsantitumoractivitiesbothinvitroandinvivo
文献类型：期刊论文
| 作者 | Ll Mengyuan2; Lv Yongcong3; Tong Linjiang3; Peng Ting3; Qu Rong3; Zhang Tao1; Sun Yiming3; Chen Yi3 ; Wei Lixin2; Geng Meiyu3
|
| 刊名 | actapharmacologicasinica
 |
| 出版日期 | 2016 |
| 卷号 | 37期号:3页码:398 |
| 关键词 | DW10075 VEGF/VEGF receptor inhibitor Antitumor Angiogenesis U87-MG human glioblastoma |
| ISSN号 | 1671-4083 |
| 英文摘要 | Aim: Targeting the VEGF Methods: In vitro tyrosine kinase activity was measured using ELISA, and intracellular signaling pathway proteins were detected by Western blot analysis. Endothelial cell proliferation was examined with CCK-8 assays, and tumor cell proliferation was determined with SRB assays. Cell migration, tube formation and rat aortic ring assays were used to detect antiangiogenic activity. Antitumor efficacy was further evaluated in U87-MG human glioblastoma xenograft tumors in nude mice receiving DW10075 (500 mg·kg ?1 ·d ?1 , po ) for two weeks. Results: Among a panel of 21 kinases tested, DW10075 selectively inhibited VEGFR-1, VEGFR-2 and VEGFR-3 (the IC 50 values were 6.4, 0.69 and 5.5 nmol 50 values ranging from 2.2 μmol Conclusion: DW10075 is a potent and highly selective inhibitor of VEGFR that deserves further development. |
| 语种 | 英语 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/287081]  |
| 专题 | 中国科学院上海药物研究所 |
| 作者单位 | 1.中国科学院大学 2.中国科学院西北高原生物研究所 3.中国科学院上海药物研究所 |
| 推荐引用方式 GB/T 7714 | Ll Mengyuan,Lv Yongcong,Tong Linjiang,et al. dw10075anovelselectiveandsmallmoleculeinhibitorofvegfrexhibitsantitumoractivitiesbothinvitroandinvivo[J]. actapharmacologicasinica,2016,37(3):398. |
| APA | Ll Mengyuan.,Lv Yongcong.,Tong Linjiang.,Peng Ting.,Qu Rong.,...&Ding Jian.(2016).dw10075anovelselectiveandsmallmoleculeinhibitorofvegfrexhibitsantitumoractivitiesbothinvitroandinvivo.actapharmacologicasinica,37(3),398. |
| MLA | Ll Mengyuan,et al."dw10075anovelselectiveandsmallmoleculeinhibitorofvegfrexhibitsantitumoractivitiesbothinvitroandinvivo".actapharmacologicasinica 37.3(2016):398. |
入库方式： OAI收割
来源：上海药物研究所
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