w2476amelioratescelldysfunctionandexertstherapeuticeffectsinmousemodelsofdiabetesviamodulationofthethioredoxininteractingproteinsignalingpathway
文献类型：期刊论文
| 作者 | Ll Ting2; Lin Guangyao3; Zhong Li2; Zhou Yan2; Wang Jia2 ; Zhu Yue2; Feng Yang2; Cai Xiaoqing2; Liu Qing2; Nosjean Olivier1
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| 刊名 | actapharmacologicasinica
 |
| 出版日期 | 2017 |
| 卷号 | 38期号:7页码:1022 |
| 关键词 | diabetes glucose TXNIP p-cells W2476 high-throughput screening |
| ISSN号 | 1671-4083 |
| DOI | 10.1038/aps.2017.15 |
| 英文摘要 | Recent evidence shows that high glucose levels recruit carbohydrate response element-binding protein, which binds the promoter of thioredoxin-interacting protein (txnip), thereby regulating its expression in β-cells. Overexpression of txnip not only induces β-cell apoptosis but also reduces insulin production. Thus, the discovery of compounds that either inhibit TXNIP activity or suppress its expression was the focus of the present study. INS-1E cells stably transfected with either a txnip proximal glucose response element connected to a luciferase reporter plasmid (BG73) or full-length txnip promoter connected to a luciferase reporter plasmid (CL108) were used in primary and secondary high-throughput screening campaigns, respectively. From 256 000 synthetic compounds, a small molecule compound, W2476 9-((1-(4-acetyl-phenyloxy)-ethyl)-2-)adenine |
| 语种 | 英语 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/287141]  |
| 专题 | 中国科学院上海药物研究所 |
| 作者单位 | 1.Pole d'Expertise Biotechnologie, Chimie et Biologie, Institut de Recherches SERVIER 2.中国科学院上海药物研究所 3.中国科学院大学 |
| 推荐引用方式 GB/T 7714 | Ll Ting,Lin Guangyao,Zhong Li,et al. w2476amelioratescelldysfunctionandexertstherapeuticeffectsinmousemodelsofdiabetesviamodulationofthethioredoxininteractingproteinsignalingpathway[J]. actapharmacologicasinica,2017,38(7):1022. |
| APA | Ll Ting.,Lin Guangyao.,Zhong Li.,Zhou Yan.,Wang Jia.,...&Wang Mingwei.(2017).w2476amelioratescelldysfunctionandexertstherapeuticeffectsinmousemodelsofdiabetesviamodulationofthethioredoxininteractingproteinsignalingpathway.actapharmacologicasinica,38(7),1022. |
| MLA | Ll Ting,et al."w2476amelioratescelldysfunctionandexertstherapeuticeffectsinmousemodelsofdiabetesviamodulationofthethioredoxininteractingproteinsignalingpathway".actapharmacologicasinica 38.7(2017):1022. |
入库方式： OAI收割
来源：上海药物研究所
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